5-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-2,4-difluorotoluene

Base Information

Chemical Name:5-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-2,4-difluorotoluene
CAS No.:333447-47-5
Molecular Formula:C₂₆H₂₀Cl₂F₂O₅
Molecular Weight:521.345
Hs Code.:

Synonyms:5-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-2,4-difluorotoluene

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Chemical Property of 5-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-2,4-difluorotoluene

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Technology Process of 5-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-2,4-difluorotoluene

There total 5 articles about 5-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-2,4-difluorotoluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 21740-23-8
3,5-O-bis(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride

: 333447-42-0
1,5-difluoro-2-iodo-4-methylbenzene

: 333447-47-5
5-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-2,4-difluorotoluene

: 333447-46-4
5-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-2,4-difluorotoluene

Guidance literature:: 3,5-O-bis(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride; With iodine; magnesium; In tetrahydrofuran; at 40 ℃; for 1h;

With cadmium(II) chloride; for 1h; Heating;

1,5-difluoro-2-iodo-4-methylbenzene; at 25 ℃; for 12h;
DOI:10.1081/NCN-100001435

Reference yield:

: 452-76-6
2,4-difluorotoluene

: 333447-47-5
5-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-2,4-difluorotoluene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 85 percent / N-iodosuccinimide / trifluoroacetic acid / 12 h / 25 °C

2.1: Mg; I₂ / tetrahydrofuran / 1 h / 40 °C

2.2: CdCl₂ / 1 h / Heating

2.3: 11 percent / 12 h / 25 °C

With N-iodo-succinimide; iodine; magnesium; In tetrahydrofuran; trifluoroacetic acid;
DOI:10.1081/NCN-100001435

Reference yield:

: 122-01-0
4-chloro-benzoyl chloride

: 333447-47-5
5-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-2,4-difluorotoluene

Guidance literature:: Multi-step reaction with 2 steps

1.1: AcCl; MeOH / 0.75 h / 25 °C

1.2: pyridine; DMAP / 0 - 25 °C

1.3: 82 percent / HCl gas / diethyl ether; acetic acid / 0.17 h / 0 °C

2.1: Mg; I₂ / tetrahydrofuran / 1 h / 40 °C

2.2: CdCl₂ / 1 h / Heating

2.3: 11 percent / 12 h / 25 °C

With methanol; iodine; magnesium; acetyl chloride; In tetrahydrofuran;
DOI:10.1081/NCN-100001435