(R)-ethyl 2-(N-(4-amino-1-phenylbutan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate trifluoroacetate

Base Information

Chemical Name:(R)-ethyl 2-(N-(4-amino-1-phenylbutan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate trifluoroacetate
CAS No.:1433993-00-0
Molecular Formula:C₂HF₃O₂*C₂₁H₂₅F₃N₂O₅S
Molecular Weight:588.525
Hs Code.:

Synonyms:(R)-ethyl 2-(N-(4-amino-1-phenylbutan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate trifluoroacetate

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Chemical Property of (R)-ethyl 2-(N-(4-amino-1-phenylbutan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate trifluoroacetate

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Technology Process of (R)-ethyl 2-(N-(4-amino-1-phenylbutan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate trifluoroacetate

There total 3 articles about (R)-ethyl 2-(N-(4-amino-1-phenylbutan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1433992-98-3
(R)-ethyl 2-(N-(1-cyano-3-phenylpropan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate

: 76-05-1
trifluoroacetic acid

: 1433993-00-0
(R)-ethyl 2-(N-(4-amino-1-phenylbutan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate trifluoroacetate

Guidance literature:: With platinum(IV) oxide; platinum on activated charcoal; hydrogen; In methanol; for 12h; under 2482.38 Torr;

Reference yield:

: 1433992-96-1
(R)-N-(1-cyano-3-phenylpropan-2-yl)-2-(trifluoromethoxy)benzenesulfonamide

: 1433993-00-0
(R)-ethyl 2-(N-(4-amino-1-phenylbutan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2: platinum on activated charcoal; platinum(IV) oxide; hydrogen / methanol / 12 h / 2482.38 Torr

With platinum(IV) oxide; platinum on activated charcoal; hydrogen; potassium carbonate; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 103008-51-1
2-(trifluoromethoxy)benzenesulfonyl chloride

: 1433993-00-0
(R)-ethyl 2-(N-(4-amino-1-phenylbutan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 12 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

3: platinum on activated charcoal; platinum(IV) oxide; hydrogen / methanol / 12 h / 2482.38 Torr

With platinum(IV) oxide; platinum on activated charcoal; hydrogen; potassium carbonate; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;