(R)-2-(N-(4-amino-1-phenylbutan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid trifluoroacetate

Base Information

Chemical Name:(R)-2-(N-(4-amino-1-phenylbutan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid trifluoroacetate
CAS No.:1433993-04-4
Molecular Formula:C₂HF₃O₂*C₁₉H₂₁F₃N₂O₅S
Molecular Weight:560.471
Hs Code.:

Synonyms:(R)-2-(N-(4-amino-1-phenylbutan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid trifluoroacetate

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Chemical Property of (R)-2-(N-(4-amino-1-phenylbutan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid trifluoroacetate

Chemical Property:

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Technology Process of (R)-2-(N-(4-amino-1-phenylbutan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid trifluoroacetate

There total 6 articles about (R)-2-(N-(4-amino-1-phenylbutan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1433993-02-2
(R)-2-(N-(4-((tert-butoxycarbonyl)amino)-1-phenylbutan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid

: 76-05-1
trifluoroacetic acid

: 1433993-04-4
(R)-2-(N-(4-amino-1-phenylbutan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid trifluoroacetate

Guidance literature:: In dichloromethane;

Reference yield:

: 1433992-96-1
(R)-N-(1-cyano-3-phenylpropan-2-yl)-2-(trifluoromethoxy)benzenesulfonamide

: 1433993-04-4
(R)-2-(N-(4-amino-1-phenylbutan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2: platinum on activated charcoal; platinum(IV) oxide; hydrogen / methanol / 12 h / 2482.38 Torr

3: dmap; triethylamine / dichloromethane / 12 h / 20 °C

4: lithium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

5: dichloromethane

With dmap; platinum(IV) oxide; platinum on activated charcoal; water; hydrogen; potassium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1433993-01-1
(R)-ethyl 2-(N-(4-((tert-butoxycarbonyl)amino)-1-phenylbutan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate

: 1433993-04-4
(R)-2-(N-(4-amino-1-phenylbutan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

2: dichloromethane

With water; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;