(R)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazepan-2-one

Base Information

Chemical Name:(R)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazepan-2-one
CAS No.:1433993-05-5
Molecular Formula:C₁₉H₁₉F₃N₂O₄S
Molecular Weight:428.432
Hs Code.:

Synonyms:(R)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazepan-2-one

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Chemical Property of (R)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazepan-2-one

Chemical Property:

Purity/Quality:

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Technology Process of (R)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazepan-2-one

There total 7 articles about (R)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazepan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1433993-04-4
(R)-2-(N-(4-amino-1-phenylbutan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid trifluoroacetate

: 1433993-05-5
(R)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazepan-2-one

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 5h; Inert atmosphere;

Reference yield:

: 1433992-98-3
(R)-ethyl 2-(N-(1-cyano-3-phenylpropan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate

: 1433993-05-5
(R)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazepan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: platinum on activated charcoal; platinum(IV) oxide; hydrogen / methanol / 12 h / 2482.38 Torr

2: dmap; triethylamine / dichloromethane / 12 h / 20 °C

3: lithium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

4: dichloromethane

5: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere

With dmap; platinum(IV) oxide; platinum on activated charcoal; water; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1433992-96-1
(R)-N-(1-cyano-3-phenylpropan-2-yl)-2-(trifluoromethoxy)benzenesulfonamide

: 1433993-05-5
(R)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazepan-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2: platinum on activated charcoal; platinum(IV) oxide; hydrogen / methanol / 12 h / 2482.38 Torr

3: dmap; triethylamine / dichloromethane / 12 h / 20 °C

4: lithium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

5: dichloromethane

6: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere

With dmap; platinum(IV) oxide; platinum on activated charcoal; water; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;