ethyl 2-{[4-{[6-(methylsulfonyl)pyridin-3-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)phenyl]hydrazono}propanoate

Base Information

Chemical Name:ethyl 2-{[4-{[6-(methylsulfonyl)pyridin-3-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)phenyl]hydrazono}propanoate
CAS No.:1233541-01-9
Molecular Formula:C₂₂H₂₇N₃O₇S
Molecular Weight:477.538
Hs Code.:

Synonyms:ethyl 2-{[4-{[6-(methylsulfonyl)pyridin-3-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)phenyl]hydrazono}propanoate

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Chemical Property of ethyl 2-{[4-{[6-(methylsulfonyl)pyridin-3-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)phenyl]hydrazono}propanoate

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Technology Process of ethyl 2-{[4-{[6-(methylsulfonyl)pyridin-3-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)phenyl]hydrazono}propanoate

There total 5 articles about ethyl 2-{[4-{[6-(methylsulfonyl)pyridin-3-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)phenyl]hydrazono}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 609-14-3
2-acetylpropanoic acid ethyl ester

: 1233541-00-8
4-{[6-(Methylsulfonyl)pyridin-3-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)aniline

: 1233541-01-9
ethyl 2-{[4-{[6-(methylsulfonyl)pyridin-3-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)phenyl]hydrazono}propanoate

Guidance literature:: 4-{[6-(Methylsulfonyl)pyridin-3-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)aniline; With hydrogenchloride; sodium nitrite; In water; acetonitrile; for 0.5h; Cooling with ice;

2-acetylpropanoic acid ethyl ester; With potassium hydroxide; In ethanol; water; acetonitrile; at -20 ℃; for 0.5h;

Reference yield:

: 134419-59-3
4-oxanyl methanesulfonate

: 1233541-01-9
ethyl 2-{[4-{[6-(methylsulfonyl)pyridin-3-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)phenyl]hydrazono}propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 110 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 6 h / 50 °C / 3750.38 Torr

4.1: hydrogenchloride; sodium nitrite / acetonitrile; water / 0.5 h / Cooling with ice

4.2: 0.5 h / -20 °C

With hydrogenchloride; hydrogen; potassium carbonate; sodium nitrite; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 446-36-6
5-fluoro-2-nitrophenol

: 1233541-01-9
ethyl 2-{[4-{[6-(methylsulfonyl)pyridin-3-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)phenyl]hydrazono}propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 110 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 6 h / 50 °C / 3750.38 Torr

4.1: hydrogenchloride; sodium nitrite / acetonitrile; water / 0.5 h / Cooling with ice

4.2: 0.5 h / -20 °C

With hydrogenchloride; hydrogen; potassium carbonate; sodium nitrite; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;