methyl 3-[(5-{4-[5-(cyclopropylmethyl)-1H-imidazol-2-yl]-3-fluorophenyl}-4-methylpyridin-2-yl)oxy]-2,2-dimethylpropanoate

Base Information

Chemical Name:methyl 3-[(5-{4-[5-(cyclopropylmethyl)-1H-imidazol-2-yl]-3-fluorophenyl}-4-methylpyridin-2-yl)oxy]-2,2-dimethylpropanoate
CAS No.:1383001-17-9
Molecular Formula:C₂₅H₂₈FN₃O₃
Molecular Weight:437.514
Hs Code.:

Synonyms:methyl 3-[(5-{4-[5-(cyclopropylmethyl)-1H-imidazol-2-yl]-3-fluorophenyl}-4-methylpyridin-2-yl)oxy]-2,2-dimethylpropanoate

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Chemical Property of methyl 3-[(5-{4-[5-(cyclopropylmethyl)-1H-imidazol-2-yl]-3-fluorophenyl}-4-methylpyridin-2-yl)oxy]-2,2-dimethylpropanoate

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Technology Process of methyl 3-[(5-{4-[5-(cyclopropylmethyl)-1H-imidazol-2-yl]-3-fluorophenyl}-4-methylpyridin-2-yl)oxy]-2,2-dimethylpropanoate

There total 5 articles about methyl 3-[(5-{4-[5-(cyclopropylmethyl)-1H-imidazol-2-yl]-3-fluorophenyl}-4-methylpyridin-2-yl)oxy]-2,2-dimethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 658076-48-3
1-bromo-3-cyclopropylpropan-2-one

: 1383000-23-4
methyl 3-{[5-(4-carbamimidoyl-3-fluorophenyl)-4-methyl-pyridin-2-yl]oxy}-2,2-dimethylpropanoate acetic acid salt

: 1383001-17-9
methyl 3-[(5-{4-[5-(cyclopropylmethyl)-1H-imidazol-2-yl]-3-fluorophenyl}-4-methylpyridin-2-yl)oxy]-2,2-dimethylpropanoate

Guidance literature:: With potassium carbonate; In dichloromethane; water; at 40 ℃; for 5h;

Reference yield:

: 105942-08-3
4-bromo-6-fluorobenzonitrile

: 1383001-17-9
methyl 3-[(5-{4-[5-(cyclopropylmethyl)-1H-imidazol-2-yl]-3-fluorophenyl}-4-methylpyridin-2-yl)oxy]-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 7 h / 60 °C / Inert atmosphere

2.1: hydroxylamine / tetrahydrofuran; methanol; water / 5 h / 80 °C

3.1: 5 h / 20 °C

3.2: 13 h / 20 °C

4.1: potassium carbonate / dichloromethane; water / 5 h / 40 °C

With hydroxylamine; sodium carbonate; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1383000-29-0
methyl 2,2-dimethyl-3-{[4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]oxy}propanoate

: 1383001-17-9
methyl 3-[(5-{4-[5-(cyclopropylmethyl)-1H-imidazol-2-yl]-3-fluorophenyl}-4-methylpyridin-2-yl)oxy]-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 7 h / 60 °C / Inert atmosphere

2.1: hydroxylamine / tetrahydrofuran; methanol; water / 5 h / 80 °C

3.1: 5 h / 20 °C

3.2: 13 h / 20 °C

4.1: potassium carbonate / dichloromethane; water / 5 h / 40 °C

With hydroxylamine; sodium carbonate; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;