methyl 3-{[5-(4-carbamimidoyl-3-fluorophenyl)-4-methyl-pyridin-2-yl]oxy}-2,2-dimethylpropanoate acetic acid salt

Base Information

Chemical Name:methyl 3-{[5-(4-carbamimidoyl-3-fluorophenyl)-4-methyl-pyridin-2-yl]oxy}-2,2-dimethylpropanoate acetic acid salt
CAS No.:1383000-23-4
Molecular Formula:C₂H₄O₂*C₁₉H₂₂FN₃O₃
Molecular Weight:419.453
Hs Code.:

Synonyms:methyl 3-{[5-(4-carbamimidoyl-3-fluorophenyl)-4-methyl-pyridin-2-yl]oxy}-2,2-dimethylpropanoate acetic acid salt

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Chemical Property of methyl 3-{[5-(4-carbamimidoyl-3-fluorophenyl)-4-methyl-pyridin-2-yl]oxy}-2,2-dimethylpropanoate acetic acid salt

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Technology Process of methyl 3-{[5-(4-carbamimidoyl-3-fluorophenyl)-4-methyl-pyridin-2-yl]oxy}-2,2-dimethylpropanoate acetic acid salt

There total 5 articles about methyl 3-{[5-(4-carbamimidoyl-3-fluorophenyl)-4-methyl-pyridin-2-yl]oxy}-2,2-dimethylpropanoate acetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383000-31-4
methyl 3-({5-[3-fluoro-4-(N-hydroxycarbamimidoyl)phenyl]-4-methyl-pyridin-2-yl}oxy)-2,2-dimethylpropanoate

: 108-24-7
acetic anhydride

: 64-19-7,77671-22-8
acetic acid

: 1383000-23-4
methyl 3-{[5-(4-carbamimidoyl-3-fluorophenyl)-4-methyl-pyridin-2-yl]oxy}-2,2-dimethylpropanoate acetic acid salt

Guidance literature:: methyl 3-({5-[3-fluoro-4-(N-hydroxycarbamimidoyl)phenyl]-4-methyl-pyridin-2-yl}oxy)-2,2-dimethylpropanoate; acetic anhydride; acetic acid; at 20 ℃; for 5h;

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 13h;

Reference yield:

: 105942-08-3
4-bromo-6-fluorobenzonitrile

: 1383000-23-4
methyl 3-{[5-(4-carbamimidoyl-3-fluorophenyl)-4-methyl-pyridin-2-yl]oxy}-2,2-dimethylpropanoate acetic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 7 h / 60 °C / Inert atmosphere

2.1: hydroxylamine / tetrahydrofuran; methanol; water / 5 h / 80 °C

3.1: 5 h / 20 °C

3.2: 13 h / 20 °C

With hydroxylamine; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1383000-29-0
methyl 2,2-dimethyl-3-{[4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]oxy}propanoate

: 1383000-23-4
methyl 3-{[5-(4-carbamimidoyl-3-fluorophenyl)-4-methyl-pyridin-2-yl]oxy}-2,2-dimethylpropanoate acetic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 7 h / 60 °C / Inert atmosphere

2.1: hydroxylamine / tetrahydrofuran; methanol; water / 5 h / 80 °C

3.1: 5 h / 20 °C

3.2: 13 h / 20 °C

With hydroxylamine; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;