methyl 3-{[5-(4-cyano-3-fluorophenyl)-4-methylpyridin-2-yl]oxy}-2,2-dimethylpropanoate

Base Information

Chemical Name:methyl 3-{[5-(4-cyano-3-fluorophenyl)-4-methylpyridin-2-yl]oxy}-2,2-dimethylpropanoate
CAS No.:1383000-30-3
Molecular Formula:C₁₉H₁₉FN₂O₃
Molecular Weight:342.37
Hs Code.:

Synonyms:methyl 3-{[5-(4-cyano-3-fluorophenyl)-4-methylpyridin-2-yl]oxy}-2,2-dimethylpropanoate

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Chemical Property of methyl 3-{[5-(4-cyano-3-fluorophenyl)-4-methylpyridin-2-yl]oxy}-2,2-dimethylpropanoate

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Technology Process of methyl 3-{[5-(4-cyano-3-fluorophenyl)-4-methylpyridin-2-yl]oxy}-2,2-dimethylpropanoate

There total 1 articles about methyl 3-{[5-(4-cyano-3-fluorophenyl)-4-methylpyridin-2-yl]oxy}-2,2-dimethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383000-29-0
methyl 2,2-dimethyl-3-{[4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]oxy}propanoate

: 105942-08-3
4-bromo-6-fluorobenzonitrile

: 1383000-30-3
methyl 3-{[5-(4-cyano-3-fluorophenyl)-4-methylpyridin-2-yl]oxy}-2,2-dimethylpropanoate

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; N,N-dimethyl-formamide; at 60 ℃; for 7h; Inert atmosphere;

Reference yield:

: 1383000-30-3
methyl 3-{[5-(4-cyano-3-fluorophenyl)-4-methylpyridin-2-yl]oxy}-2,2-dimethylpropanoate

: 1383000-31-4
methyl 3-({5-[3-fluoro-4-(N-hydroxycarbamimidoyl)phenyl]-4-methyl-pyridin-2-yl}oxy)-2,2-dimethylpropanoate

Guidance literature:: With hydroxylamine; In tetrahydrofuran; methanol; water; at 80 ℃; for 5h;

Reference yield:

: 1383000-30-3
methyl 3-{[5-(4-cyano-3-fluorophenyl)-4-methylpyridin-2-yl]oxy}-2,2-dimethylpropanoate

: 1383000-32-5
3-{[5-(3-fluoro-4-{5-[1-(trifluoromethyl)cyclopropyl]-1H-imidazol-2-yl}phenyl)-4-methylpyridin-2-yl]oxy}-2,2-dimethylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine / tetrahydrofuran; methanol; water / 5 h / 80 °C

2.1: 5 h / 20 °C

2.2: 13 h / 20 °C

3.1: potassium carbonate / dichloromethane; water / 8 h / 50 °C

4.1: water; sodium hydroxide / tetrahydrofuran; methanol / 3 h / 50 °C

With water; hydroxylamine; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;