(2S,6R)-4-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-2,6-dimethylmorpholine

Base Information

Chemical Name:(2S,6R)-4-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-2,6-dimethylmorpholine
CAS No.:1263868-48-9
Molecular Formula:C₁₉H₂₁ClFN₃O
Molecular Weight:361.847
Hs Code.:

Synonyms:(2S,6R)-4-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-2,6-dimethylmorpholine

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Chemical Property of (2S,6R)-4-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-2,6-dimethylmorpholine

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Technology Process of (2S,6R)-4-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-2,6-dimethylmorpholine

There total 7 articles about (2S,6R)-4-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-2,6-dimethylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: cis-2,6-dimethylmorpholine

: 1263868-30-9
2,4-dichloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

: 1263868-48-9
(2S,6R)-4-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-2,6-dimethylmorpholine

Guidance literature:: In methanol; at 20 ℃;

Reference yield:

: 120-92-3
cyclopentanone

: 1263868-48-9
(2S,6R)-4-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-2,6-dimethylmorpholine

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 0 °C / Reflux

2: formic acid; dihydrogen peroxide / water / 20 °C

3: 3 h / 58 - 130 °C

4: ammonium hydroxide / water / 100 °C / High-pressure vessel

5: N,N-dimethyl-aniline; trichlorophosphate / 110 °C

6: methanol / 20 °C

With ammonium hydroxide; formic acid; dihydrogen peroxide; N,N-dimethyl-aniline; trichlorophosphate; In tetrahydrofuran; methanol; water;

Reference yield:

: 352-13-6
4-flourophenylmagnesium bromide

: 1263868-48-9
(2S,6R)-4-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-2,6-dimethylmorpholine

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 0 °C / Reflux

2: formic acid; dihydrogen peroxide / water / 20 °C

3: 3 h / 58 - 130 °C

4: ammonium hydroxide / water / 100 °C / High-pressure vessel

5: N,N-dimethyl-aniline; trichlorophosphate / 110 °C

6: methanol / 20 °C

With ammonium hydroxide; formic acid; dihydrogen peroxide; N,N-dimethyl-aniline; trichlorophosphate; In tetrahydrofuran; methanol; water;