H-D-Glu(D-Trp-O-CH(CH₃)-O-CO-O-cyclohexyl)-O-Et hydrochloride

Base Information

• Chemical Name: H-D-Glu(D-Trp-O-CH(CH₃)-O-CO-O-cyclohexyl)-O-Et hydrochloride
• CAS No.: 1401719-45-6
• Molecular Formula: C₂₇H₃₇N₃O₈*ClH
• Molecular Weight: 568.067
• Mol file: 1401719-45-6.mol

Synonyms:H-D-Glu(D-Trp-O-CH(CH₃)-O-CO-O-cyclohexyl)-O-Et hydrochloride

Chemical Property of H-D-Glu(D-Trp-O-CH(CH₃)-O-CO-O-cyclohexyl)-O-Et hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of H-D-Glu(D-Trp-O-CH(CH₃)-O-CO-O-cyclohexyl)-O-Et hydrochloride

There total 4 articles about H-D-Glu(D-Trp-O-CH(CH₃)-O-CO-O-cyclohexyl)-O-Et hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

Cbz-D-Glu(D-Trp-O-CH(CH3)-O-CO-O-cyclohexyl)-O-Et (1401719-90-1) → H-D-Glu(D-Trp-O-CH(CH3)-O-CO-O-cyclohexyl)-O-Et hydrochloride (1401719-45-6)

Guidance literature:

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In diethyl ether; for 1h; under 1034.32 - 1292.9 Torr;

Reference yield:

D-tryptophan (153-94-6,27732-43-0,80206-30-0,27813-82-7) → H-D-Glu(D-Trp-O-CH(CH3)-O-CO-O-cyclohexyl)-O-Et hydrochloride (1401719-45-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-pyrrolidine-2,5-dione / N,N-dimethyl-formamide / 20 °C / Cooling with ice-water

1.2: 20 °C / Cooling with ice-water

1.3: Cooling with ice

2.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 20 - 40 °C

3.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / diethyl ether / 1 h / 1034.32 - 1292.9 Torr

With hydrogenchloride; 1-hydroxy-pyrrolidine-2,5-dione; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium iodide; palladium 10% on activated carbon; In diethyl ether; N,N-dimethyl-formamide;

Reference yield:

α-ethyl D-N-carbobenzoxyglutamate (97996-97-9) → H-D-Glu(D-Trp-O-CH(CH3)-O-CO-O-cyclohexyl)-O-Et hydrochloride (1401719-45-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-pyrrolidine-2,5-dione / N,N-dimethyl-formamide / 20 °C / Cooling with ice-water

1.2: 20 °C / Cooling with ice-water

1.3: Cooling with ice

2.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 20 - 40 °C

3.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / diethyl ether / 1 h / 1034.32 - 1292.9 Torr

With hydrogenchloride; 1-hydroxy-pyrrolidine-2,5-dione; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium iodide; palladium 10% on activated carbon; In diethyl ether; N,N-dimethyl-formamide;

upstream raw materials:

D-tryptophan

α-ethyl D-N-carbobenzoxyglutamate

Cbz-D-Glu(D-Trp-OH)-O-Et

Cbz-D-Glu(D-Trp-O-CH(CH₃)-O-CO-O-cyclohexyl)-O-Et