N₅-(2-hydroxy-1,1-dimethylethyl)-3-(2,4-diflurophenyl)-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,4-diene-5-carboxamide

Base Information

• Chemical Name: N₅-(2-hydroxy-1,1-dimethylethyl)-3-(2,4-diflurophenyl)-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,4-diene-5-carboxamide
• CAS No.: 1024004-53-2
• Molecular Formula: C₁₉H₂₁F₂N₃O₂
• Molecular Weight: 361.391

Synonyms:N₅-(2-hydroxy-1,1-dimethylethyl)-3-(2,4-diflurophenyl)-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,4-diene-5-carboxamide

Chemical Property of N₅-(2-hydroxy-1,1-dimethylethyl)-3-(2,4-diflurophenyl)-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,4-diene-5-carboxamide

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Technology Process of N₅-(2-hydroxy-1,1-dimethylethyl)-3-(2,4-diflurophenyl)-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,4-diene-5-carboxamide

There total 1 articles about N₅-(2-hydroxy-1,1-dimethylethyl)-3-(2,4-diflurophenyl)-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,4-diene-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

3-(2,4-difluorophenyl)-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2(6),4-dien-5-carboxylic acid (916591-87-2,916591-89-4,916591-88-3) + 2-Amino-2-methyl-1-propanol (124-68-5) → N5-(2-hydroxy-1,1-dimethylethyl)-3-(2,4-diflurophenyl)-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2(6),4-diene-5-carboxamide (1024004-53-2)

Guidance literature:

3-(2,4-difluorophenyl)-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,4-dien-5-carboxylic acid; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 - 35 ℃; for 0.5h;

2-Amino-2-methyl-1-propanol; In N,N-dimethyl-formamide; at 20 - 35 ℃; for 8 - 16h;

Reference yield: 63.0%

N5-(2-hydroxy-1,1-dimethylethyl)-3-(2,4-diflurophenyl)-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2(6),4-diene-5-carboxamide (1024004-53-2) → 2-[5-(2,4-diflurophenyl)-4,5-diazatricyclo[5.2.1.0(2,6)]deca-2(6),3-dien-3-yl]-4,4-dimethyl-4,5-dihydro-1,3-oxazole (1024005-05-7)

Guidance literature:

With thionyl chloride; In ethyl acetate; at 20 - 35 ℃; for 2h;

upstream raw materials:

3-(2,4-difluorophenyl)-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,4-dien-5-carboxylic acid

2-Amino-2-methyl-1-propanol

Downstream raw materials:

2-[5-(2,4-diflurophenyl)-4,5-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,3-dien-3-yl]-4,4-dimethyl-4,5-dihydro-1,3-oxazole

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