benzyl (2S)-2-({(1-R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-5-nitro-2-phenyl-3,4-dihydropyridine-1(2h)-carboxylate

Base Information

Chemical Name:benzyl (2S)-2-({(1-R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-5-nitro-2-phenyl-3,4-dihydropyridine-1(2h)-carboxylate
CAS No.:873948-11-9
Molecular Formula:C₃₀H₂₆F₆N₂O₅
Molecular Weight:608.537
Hs Code.:

Synonyms:benzyl (2S)-2-({(1-R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-5-nitro-2-phenyl-3,4-dihydropyridine-1(2h)-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl (2S)-2-({(1-R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-5-nitro-2-phenyl-3,4-dihydropyridine-1(2h)-carboxylate

Chemical Property:

Purity/Quality:: 95%-98% ^*data from raw suppliers

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Technology Process of benzyl (2S)-2-({(1-R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-5-nitro-2-phenyl-3,4-dihydropyridine-1(2h)-carboxylate

There total 6 articles about benzyl (2S)-2-({(1-R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-5-nitro-2-phenyl-3,4-dihydropyridine-1(2h)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 552293-34-2
benzyl (2S)-2-({(1-R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-2-phenyl-3,4-dihydropyridine-1(2h)-carboxylate

: 873948-11-9
benzyl (2S)-2-({(1-R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-5-nitro-2-phenyl-3,4-dihydropyridine-1(2h)-carboxylate

Guidance literature:: With nitronium tetrafluoborate;
DOI:10.1016/j.tetlet.2013.08.131

Reference yield:

: 530441-95-3
(R)-1-(1-(bromomethoxy)ethyl)-3,5-bis(trifluoromethyl)benzene

: 873948-11-9
benzyl (2S)-2-({(1-R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-5-nitro-2-phenyl-3,4-dihydropyridine-1(2h)-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide

2.1: lithium borohydride / 0 °C

3.1: potassium hexamethylsilazane / -78 - 20 °C

4.1: hydrogen; platinum(IV) oxide

4.2: 80 °C

5.1: nitronium tetrafluoborate

With platinum(IV) oxide; lithium borohydride; nitronium tetrafluoborate; hydrogen; potassium hexamethylsilazane; lithium diisopropyl amide; 3.1: |Wittig Olefination;
DOI:10.1016/j.tetlet.2013.08.131

Reference yield:

: C₃₄H₂₇F₆NO₅

: 873948-11-9
benzyl (2S)-2-({(1-R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-5-nitro-2-phenyl-3,4-dihydropyridine-1(2h)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium borohydride / 0 °C

2.1: potassium hexamethylsilazane / -78 - 20 °C

3.1: hydrogen; platinum(IV) oxide

3.2: 80 °C

4.1: nitronium tetrafluoborate

With platinum(IV) oxide; lithium borohydride; nitronium tetrafluoborate; hydrogen; potassium hexamethylsilazane; 2.1: |Wittig Olefination;
DOI:10.1016/j.tetlet.2013.08.131