methyl 2-{[N-(tert-butoxycarbonyl)amino]methyl}-3-phenylpropanoate

Base Information

• Chemical Name: methyl 2-{[N-(tert-butoxycarbonyl)amino]methyl}-3-phenylpropanoate
• CAS No.: 1023326-71-7
• Molecular Formula: C₁₆H₂₃NO₄
• Molecular Weight: 293.363
• Mol file: 1023326-71-7.mol

Synonyms:methyl 2-{[N-(tert-butoxycarbonyl)amino]methyl}-3-phenylpropanoate

Chemical Property of methyl 2-{[N-(tert-butoxycarbonyl)amino]methyl}-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-{[N-(tert-butoxycarbonyl)amino]methyl}-3-phenylpropanoate

There total 4 articles about methyl 2-{[N-(tert-butoxycarbonyl)amino]methyl}-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methyl 2-{[N-benzyl(tert-butoxycarbonyl)amino]methyl}-3-phenylpropanoate (1023326-66-0) + di-tert-butyl dicarbonate (24424-99-5) → methyl 2-{[N-(tert-butoxycarbonyl)amino]methyl}-3-phenylpropanoate (1023326-71-7)

Guidance literature:

methyl 2-{[N-benzyl(tert-butoxycarbonyl)amino]methyl}-3-phenylpropanoate; With hydrogen; palladium dichloride; In methanol; for 4h;

di-tert-butyl dicarbonate; With triethylamine; In dichloromethane; for 12h; Further stages.;

DOI:10.1016/j.tet.2008.02.024

Reference yield: 55.0%

di-tert-butyl dicarbonate (24424-99-5) + methyl benzylidenecyanoacetate (3695-84-9,14533-85-8,14533-86-9) → methyl 2-{[N-(tert-butoxycarbonyl)amino]methyl}-3-phenylpropanoate (1023326-71-7)

Guidance literature:

di-tert-butyl dicarbonate; methyl benzylidenecyanoacetate; With sodium tetrahydroborate; cobalt(II) chloride hexahydrate; In methanol; at 0 ℃;

With triethylamine; In methanol; for 0.5h;

DOI:10.3390/MOLECULES25102461

Reference yield:

benzaldehyde (100-52-7) → methyl 2-{[N-(tert-butoxycarbonyl)amino]methyl}-3-phenylpropanoate (1023326-71-7)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / methanol / 16 h / Reflux

2: cobalt(II) chloride hexahydrate; sodium tetrahydroborate / methanol / 0 - 20 °C

With piperidine; sodium tetrahydroborate; cobalt(II) chloride hexahydrate; In methanol;

DOI:10.1002/psc.2883

upstream raw materials:

methyl 2-{[N-benzyl(tert-butoxycarbonyl)amino]methyl}-3-phenylpropanoate

di-tert-butyl dicarbonate

(3R)-benzyl-3-(tert-butoxycarbonyl)amino-propanoic acid

diazomethyl-trimethyl-silane

Downstream raw materials:

(3R)-benzyl-3-(tert-butoxycarbonyl)amino-propanoic acid