(R,S)-Boc-3-amino-2-benzyl-propionic acid

Base Information

• Chemical Name: (R,S)-Boc-3-amino-2-benzyl-propionic acid
• CAS No.: 26250-90-8
• Molecular Formula: C15H21NO4
• Molecular Weight: 279.336
• Hs Code.: 29225090
• Mol file: 26250-90-8.mol

Synonyms:Hydrocinnamicacid, a-[(carboxyamino)methyl]-,N-tert-butyl ester, DL- (8CI);2-Benzyl-3-[(tert-butoxycarbonyl)amino]propanoicacid;3-[[[(1,1-Dimethylethyl)oxy]carbonyl]amino]-2-(phenylmethyl)propanoicacid;

Chemical Property of (R,S)-Boc-3-amino-2-benzyl-propionic acid

Chemical Property:

• Vapor Pressure: 1.45E-08mmHg at 25°C
• Melting Point: 74 °C(Solv: ethyl ether (60-29-7); pentane (109-66-0))
• Refractive Index: 1.524
• Boiling Point: 441.3 °C at 760 mmHg
• PKA: 4.36±0.10(Predicted)
• Flash Point: 220.7 °C
• PSA: 75.63000
• Density: 1.139 g/cm³
• LogP: 2.84550
• Storage Temp.: 2-8°C

Purity/Quality:

70% in water ^*data from raw suppliers

N-Boc-3-amino-2-benzylpropionic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R,S)-Boc-3-amino-2-benzyl-propionic acid

There total 81 articles about (R,S)-Boc-3-amino-2-benzyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(2S)-2-benzyl-3-[(t-butyloxycarbonyl)amino]propanol (341926-08-7) → (S)-2-[(tert-butoxycarbonylamino)methyl]-3-phenylpropanoic acid (26250-90-8,189619-55-4,262301-38-2)

Guidance literature:

With water; dichromic acid; In acetone; at 0 - 20 ℃;

DOI:10.1021/ja070063i

Reference yield: 91.0%

(-)-(S)-1-tert-Butoxycarbonyl-4-phenyl-2-pyrrolidinone (128372-78-1,138782-43-1,138782-44-2) → (S)-2-[(tert-butoxycarbonylamino)methyl]-3-phenylpropanoic acid (26250-90-8,189619-55-4,262301-38-2)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; for 1.5h; Ambient temperature;

DOI:10.1055/s-1991-26638

Reference yield: 89.0%

(+)-(R)-1-tert-Butoxycarbonyl-4-phenyl-2-pyrrolidinone (128372-78-1,138782-44-2,138782-43-1) → (R)-3-tert-butyloxycarbonyl-β2-homophenylalanine (26250-90-8,189619-55-4,262301-38-2)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; for 1.5h; Ambient temperature;

DOI:10.1055/s-1991-26638

upstream raw materials:

(-)-(S)-1-tert-Butoxycarbonyl-4-phenyl-2-pyrrolidinone

(2S)-2-benzyl-3-[(t-butyloxycarbonyl)amino]propanol

(S)-β-benzyl-γ-(S)-N-benzyl-α-methylbenzylamino-propylalcohol

di-tert-butyl dicarbonate

Downstream raw materials:

1,1-dimethylethyl [3-({5-(3-furanyl)-4-[1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-thienyl}amino)-3-oxo-2-(phenylmethyl)propyl]carbamate

1,1-dimethylethyl [3-oxo-2-(phenylmethyl)-3-({5-phenyl-4-[1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-thienyl}amino)propyl]carbamate

3-[(tert-butoxy)carbonylamino]-N-(6-isoquinolylcarbonylamino)-2-benzylpropanamide

methyl 2-{[N-(tert-butoxycarbonyl)amino]methyl}-3-phenylpropanoate