N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]ethyl}acetamide

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Chemical Name:N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]ethyl}acetamide
CAS No.:1253732-84-1
Molecular Formula:C₂₁H₂₄N₄O₅
Molecular Weight:412.445
Hs Code.:

Synonyms:N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]ethyl}acetamide

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Chemical Property of N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]ethyl}acetamide

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Technology Process of N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]ethyl}acetamide

There total 10 articles about N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]ethyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1253732-89-6
2-[4-(2-aminoethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-3H-pyrido[2,3-d]pyrimidin-4-one

: 75-36-5
acetyl chloride

: 1253732-84-1
N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]ethyl}acetamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 1044872-40-3
methyl 2-amino-4,6-dichloropyridine-3-carboxylate

: 1253732-84-1
N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]ethyl}acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium methylate / 5 h / Reflux

2.1: potassium hydroxide / water; ethanol / 16 h / 80 °C

2.2: pH 6

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / tetrahydrofuran / 0.17 h / 20 °C

3.2: 16 h / 20 °C

4.1: sodium hydrogen sulfate; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 16 h / 145 °C

5.1: hydrazine hydrate / ethanol / 4 h / 70 °C

6.1: pyridine / dichloromethane / 3 h / 20 °C

With 4-methyl-morpholine; pyridine; sodium hydrogen sulfate; sodium methylate; benzotriazol-1-ol; toluene-4-sulfonic acid; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water;

Reference yield:

: 1044872-41-4
methyl 2-amino-4,6-dimethoxypyridine-3-carboxylate

: 1253732-84-1
N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]ethyl}acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / water; ethanol / 16 h / 80 °C

1.2: pH 6

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / tetrahydrofuran / 0.17 h / 20 °C

2.2: 16 h / 20 °C

3.1: sodium hydrogen sulfate; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 16 h / 145 °C

4.1: hydrazine hydrate / ethanol / 4 h / 70 °C

5.1: pyridine / dichloromethane / 3 h / 20 °C

With 4-methyl-morpholine; pyridine; sodium hydrogen sulfate; benzotriazol-1-ol; toluene-4-sulfonic acid; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water;