(1S)-1-(4-morpholinomethyl)-5-oxo-5-(phenylmethoxy)phentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate

Base Information

Chemical Name:(1S)-1-(4-morpholinomethyl)-5-oxo-5-(phenylmethoxy)phentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate
CAS No.:143508-53-6
Molecular Formula:C₃₅H₅₄N₂O₈
Molecular Weight:630.822
Hs Code.:

(1S)-1-(4-morpholinomethyl)-5-oxo-5-(phenylmethoxy)phentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate

Synonyms:(1S)-1-(4-morpholinomethyl)-5-oxo-5-(phenylmethoxy)phentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate

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Chemical Property of (1S)-1-(4-morpholinomethyl)-5-oxo-5-(phenylmethoxy)phentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate

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Technology Process of (1S)-1-(4-morpholinomethyl)-5-oxo-5-(phenylmethoxy)phentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate

There total 2 articles about (1S)-1-(4-morpholinomethyl)-5-oxo-5-(phenylmethoxy)phentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 121533-54-8
(4S,5R)-3-tert-Butoxycarbonyl-4-cyclohexyl-methyl-2,2-dimethyloxazolidine-5-carboxylic acid

: 137238-59-6
5-Hydroxy-6-morpholin-4-yl-hexanoic acid benzyl ester

: 147505-11-1
(1R)-1-(4-morpholinomethyl)-5-oxo-5-(phenylmethoxy)pentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate

: 143508-53-6
(1S)-1-(4-morpholinomethyl)-5-oxo-5-(phenylmethoxy)phentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate

Guidance literature:: With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 0 ℃;
DOI:10.1021/jm00099a004

Reference yield:

: 137238-88-1
4-Oxiranyl-butyric acid benzyl ester

: 143508-53-6
(1S)-1-(4-morpholinomethyl)-5-oxo-5-(phenylmethoxy)phentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate

Guidance literature:: Multi-step reaction with 2 steps

1: alumina / diethyl ether

2: 36 percent / 4-(dimethylamino)pyridine (DMAP), 3-ethyl-1-<3-(dimethylamino)propyl>carbodiimide (EDC) / CH₂Cl₂ / 0 °C

With dmap; aluminum oxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In diethyl ether; dichloromethane;
DOI:10.1021/jm00099a004