Technology Process of 2,6-difluoro-3-methyl-5-triisopropylsilyloxybenzoic acid
There total 5 articles about 2,6-difluoro-3-methyl-5-triisopropylsilyloxybenzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2,4-difluoro-5-methylphenoxy)triisopropylsilyl;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -60 ℃;
for 2h;
Inert atmosphere;
carbon dioxide;
In
tetrahydrofuran; hexane;
at -60 - 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 90 °C / Inert atmosphere
2.1: dihydrogen peroxide; water; sodium hydroxide / tetrahydrofuran / 4 h / 20 °C
3.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C
4.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -60 °C / Inert atmosphere
4.2: 1 h / -60 - 20 °C
With
1H-imidazole; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; n-butyllithium; water; dihydrogen peroxide; potassium acetate; sodium hydroxide;
In
tetrahydrofuran; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: dihydrogen peroxide; water; sodium hydroxide / tetrahydrofuran / 4 h / 20 °C
2.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C
3.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -60 °C / Inert atmosphere
3.2: 1 h / -60 - 20 °C
With
1H-imidazole; n-butyllithium; water; dihydrogen peroxide; sodium hydroxide;
In
tetrahydrofuran; hexane; N,N-dimethyl-formamide;
