Technology Process of 1-(1,3-dioxolan-2-yl)but-3-yn-2-ol
There total 1 articles about 1-(1,3-dioxolan-2-yl)but-3-yn-2-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 2 steps
1: 74 percent / PCC / CH2Cl2
2: 89 percent / EtBr, Mg / tetrahydrofuran / 24 h / Ambient temperature
With
ethidium Bromide; magnesium; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane;
DOI:10.1039/P19860000889
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90780-55-5
(±)-(4Z,8E,10Z,13Z,16Z,19Z)-7-hydroxydocosa-4,8,10,13,16,19-hexaenoic acid
- Guidance literature:
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Multi-step reaction with 8 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C
2.1: zirconocene dichloride; diisobutylaluminium hydride / tetrahydrofuran; toluene / 1 h / 0 °C
2.2: 0.33 h / -78 °C
3.1: dichloro bis(acetonitrile) palladium(II) / acetone / 48 h / 20 °C / Darkness
4.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 1 h / -78 °C
4.2: 1 h / -78 °C
5.1: diisopropylamine; tetrakis(triphenylphosphine) palladium(0) / 0.5 h
5.2: 20 °C
6.1: Zn(Cu/Ag) / methanol; water; 1,4-dioxane / 6 h / 45 °C
6.2: 48 h / 45 °C
7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
8.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C
With
1H-imidazole; dichloro bis(acetonitrile) palladium(II); tetrakis(triphenylphosphine) palladium(0); zirconocene dichloride; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; potassium hexamethylsilazane; diisobutylaluminium hydride; diisopropylamine;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/acs.joc.0c01770
