Technology Process of 3-bromo-2-ethylbenzenemethanol
There total 5 articles about 3-bromo-2-ethylbenzenemethanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-ethylbenzaldehyde;
With
aluminum (III) chloride;
In
dichloromethane;
at 0 ℃;
for 0.166667h;
With
bromine;
In
dichloromethane;
at 0 - 20 ℃;
for 22h;
With
sodium tetrahydroborate;
In
methanol;
at 20 ℃;
for 18h;
DOI:10.1021/acs.jmedchem.9b01573
- Guidance literature:
-
With
methanol; sodium tetrahydroborate;
at 0 - 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 4 h / -70 - -65 °C
2.1: n-butyllithium; isopropylmagnesium bromide / hexane; tetrahydrofuran / 1.17 h / 0 °C
2.2: 2 h / -10 - 20 °C
2.3: 0.17 h / 0 °C
3.1: hydrogenchloride / water; tetrahydrofuran / 1 h / 20 °C
4.1: sodium tetrahydroborate; methanol / 2 h / 0 - 20 °C
With
hydrogenchloride; methanol; sodium tetrahydroborate; n-butyllithium; isopropylmagnesium bromide; diisopropylamine;
In
tetrahydrofuran; hexane; water;
