(S)-2-Benzyloxycarbonylamino-4-methylsulfanyl-butyric acid 3-hydroxy-propyl ester

Base Information

Chemical Name:(S)-2-Benzyloxycarbonylamino-4-methylsulfanyl-butyric acid 3-hydroxy-propyl ester
CAS No.:203920-16-5
Molecular Formula:C₁₆H₂₃NO₅S
Molecular Weight:341.428
Hs Code.:

Synonyms:(S)-2-Benzyloxycarbonylamino-4-methylsulfanyl-butyric acid 3-hydroxy-propyl ester

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Chemical Property of (S)-2-Benzyloxycarbonylamino-4-methylsulfanyl-butyric acid 3-hydroxy-propyl ester

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Technology Process of (S)-2-Benzyloxycarbonylamino-4-methylsulfanyl-butyric acid 3-hydroxy-propyl ester

There total 3 articles about (S)-2-Benzyloxycarbonylamino-4-methylsulfanyl-butyric acid 3-hydroxy-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1152-62-1
Cbz-Met-OH

: 504-63-2
trimethyleneglycol

: 203920-16-5
(S)-2-Benzyloxycarbonylamino-4-methylsulfanyl-butyric acid 3-hydroxy-propyl ester

Guidance literature:: With dmap; 4-(dimethylamino)pyridine hydrochloride; dicyclohexyl-carbodiimide; In dichloromethane; for 6h; Heating;
DOI:10.1021/jo972133h

Reference yield:

: 63-68-3,26062-47-5,58576-49-1
L-methionine

: 203920-16-5
(S)-2-Benzyloxycarbonylamino-4-methylsulfanyl-butyric acid 3-hydroxy-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / NaHCO₃ / H₂O / 2 h / Ambient temperature

2: 79 percent / DCC, DMAP, DMAP*HCl / CH₂Cl₂ / 6 h / Heating

With dmap; 4-(dimethylamino)pyridine hydrochloride; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In dichloromethane; water;
DOI:10.1021/jo972133h

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 203920-16-5
(S)-2-Benzyloxycarbonylamino-4-methylsulfanyl-butyric acid 3-hydroxy-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / NaHCO₃ / H₂O / 2 h / Ambient temperature

2: 79 percent / DCC, DMAP, DMAP*HCl / CH₂Cl₂ / 6 h / Heating

With dmap; 4-(dimethylamino)pyridine hydrochloride; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In dichloromethane; water;
DOI:10.1021/jo972133h