-(+)-1-chloro-3-phenyl-3-(2-methoxyphenoxy)propane

Base Information

Chemical Name:-(+)-1-chloro-3-phenyl-3-(2-methoxyphenoxy)propane
CAS No.:114446-49-0
Molecular Formula:C₁₆H₁₇ClO₂
Molecular Weight:276.763
Hs Code.:

<R>-(+)-1-chloro-3-phenyl-3-(2-methoxyphenoxy)propane

Synonyms:-(+)-1-chloro-3-phenyl-3-(2-methoxyphenoxy)propane

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Chemical Property of -(+)-1-chloro-3-phenyl-3-(2-methoxyphenoxy)propane

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Technology Process of -(+)-1-chloro-3-phenyl-3-(2-methoxyphenoxy)propane

There total 6 articles about -(+)-1-chloro-3-phenyl-3-(2-methoxyphenoxy)propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 100306-34-1,125712-82-5
3-chloro-1-phenylpropanol

: 90-05-1
2-methoxy-phenol

: 114446-49-0
-(+)-1-chloro-3-phenyl-3-(2-methoxyphenoxy)propane

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In diethyl ether; at -10 ℃; for 5h;
DOI:10.1016/j.bmc.2005.04.062

Reference yield:

: 936-59-4
3-chloropropiophenone

: 114446-49-0
-(+)-1-chloro-3-phenyl-3-(2-methoxyphenoxy)propane

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / NaBH₄ / ethanol / 2 h / 20 °C

2: 93 percent / pyridine; DMAP / CH₂Cl₂ / 0 - 20 °C

3: aq. phosphate buffer; Novozyme 435 / 288 h / 30 °C / pH 7

4: 42 percent / PPh₃; diethyl azodicarboxylate / tetrahydrofuran / 20 °C

With pyridine; dmap; sodium tetrahydroborate; phosphate buffer; novozyme 435; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; 1: Reduction / 2: Esterification / 3: Hydrolysis / 4: Etherification;
DOI:10.1039/b000846j

Reference yield:

: 18776-12-0,125712-82-5
3-chloro-1-phenyl-propan-1-ol

: 114446-49-0
-(+)-1-chloro-3-phenyl-3-(2-methoxyphenoxy)propane

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / pyridine; DMAP / CH₂Cl₂ / 0 - 20 °C

2: aq. phosphate buffer; Novozyme 435 / 288 h / 30 °C / pH 7

3: 42 percent / PPh₃; diethyl azodicarboxylate / tetrahydrofuran / 20 °C

With pyridine; dmap; phosphate buffer; novozyme 435; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 1: Esterification / 2: Hydrolysis / 3: Etherification;
DOI:10.1039/b000846j