(r)-n-Methyl-3-(2-methoxyphenoxy)-3-phenylpropylamine

Base Information

• Chemical Name: (r)-n-Methyl-3-(2-methoxyphenoxy)-3-phenylpropylamine
• CAS No.: 112066-67-8
• Molecular Formula: C₁₇H₂₁NO₂
• Molecular Weight: 271.359
• UNII: ARR0KQW356
• Nikkaji Number: J259.976G
• Wikidata: Q27274089

Synonyms:(R)-Nisoxetine;Nisoxetine, (R)-;Nisoxetine, (+)-;UNII-ARR0KQW356;ARR0KQW356;(r)-n-methyl-3-(2-methoxyphenoxy)-3-phenylpropylamine;112066-67-8;Benzenepropanamine, gamma-(2-methoxyphenoxy)-N-methyl-, (R)-;Benzenepropanamine, gamma-(2-methoxyphenoxy)-N-methyl-, (gammaR)-;R-Nisoxetine;(+)-nisoxetine;SCHEMBL3892886;PD132386;Q27274089;BENZENEPROPANAMINE, .GAMMA.-(2-METHOXYPHENOXY)-N-METHYL-, (R)-;BENZENEPROPANAMINE, .GAMMA.-(2-METHOXYPHENOXY)-N-METHYL-, (.GAMMA.R)-

Chemical Property of (r)-n-Methyl-3-(2-methoxyphenoxy)-3-phenylpropylamine

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 271.157228913
• Heavy Atom Count: 20
• Complexity: 253

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CNCCC(C1=CC=CC=C1)OC2=CC=CC=C2OC
• Isomeric SMILES: CNCC[C@H](C1=CC=CC=C1)OC2=CC=CC=C2OC

Technology Process of (r)-n-Methyl-3-(2-methoxyphenoxy)-3-phenylpropylamine

There total 26 articles about (r)-n-Methyl-3-(2-methoxyphenoxy)-3-phenylpropylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(R)-N-(ethoxycarbonyl)-3-(2-methoxyphenoxy)-3-phenyl-1-propanamine → (R)-N-methyl-3-(2-methoxyphenoxy)-3-phenyl-1-propanamine (112066-67-8,57226-61-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;

DOI:10.1016/S0957-4166(02)00537-2

Reference yield: 79.0%

(R)-1-iodo-3-(2-methoxyphenoxy)-3-phenylpropane (862183-38-8) + methylamine (74-89-5) → (R)-N-methyl-3-(2-methoxyphenoxy)-3-phenyl-1-propanamine (112066-67-8,57226-61-6)

Guidance literature:

In tetrahydrofuran; water; at 20 ℃; for 3h;

DOI:10.1016/j.bmc.2005.04.062

Reference yield: 55.0%

-(+)-1-chloro-3-phenyl-3-(2-methoxyphenoxy)propane (114446-49-0) + methylamine (74-89-5) → (R)-N-methyl-3-(2-methoxyphenoxy)-3-phenyl-1-propanamine (112066-67-8,57226-61-6)

Guidance literature:

In ethanol; at 130 ℃; for 6h; Heating;

DOI:10.1039/b000846j

upstream raw materials:

2-Chloroanisole

(R)-N-methyl-3-phenyl-3-hydroxypropylamine

-(+)-1-chloro-3-phenyl-3-(2-methoxyphenoxy)propane

methylamine

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