5-(tert-butyl-diphenyl-silanyloxymethyl)-4,5-dihydro-3H-pyrrol-2-ylamine

Base Information

• Chemical Name: 5-(tert-butyl-diphenyl-silanyloxymethyl)-4,5-dihydro-3H-pyrrol-2-ylamine
• CAS No.: 869287-22-9
• Molecular Formula: C₂₁H₂₈N₂OSi
• Molecular Weight: 352.552

Synonyms:5-(tert-butyl-diphenyl-silanyloxymethyl)-4,5-dihydro-3H-pyrrol-2-ylamine

Chemical Property of 5-(tert-butyl-diphenyl-silanyloxymethyl)-4,5-dihydro-3H-pyrrol-2-ylamine

Chemical Property:

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Technology Process of 5-(tert-butyl-diphenyl-silanyloxymethyl)-4,5-dihydro-3H-pyrrol-2-ylamine

There total 5 articles about 5-(tert-butyl-diphenyl-silanyloxymethyl)-4,5-dihydro-3H-pyrrol-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-Pyroglutaminol (17342-08-4) → 5-(tert-butyl-diphenyl-silanyloxymethyl)-4,5-dihydro-3H-pyrrol-2-ylamine (869287-22-9)

Guidance literature:

Multi-step reaction with 4 steps

1: imidazole / dimethylformamide / 2 h / 20 °C

2: Lawesson's reagent / tetrahydrofuran / 2 h / 20 °C

3: CH₂Cl₂ / 5 h / 20 °C

4: NH₄Cl / methanol / 3.5 h / 50 °C

With Lawessons reagent; 1H-imidazole; ammonium chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2005.07.076

Reference yield:

2-(tert-butyl-diphenyl-silanyloxymethyl)-5-methylsulfanyl-3,4-dihydro-2H-pyrrole (852674-75-0) → 5-(tert-butyl-diphenyl-silanyloxymethyl)-4,5-dihydro-3H-pyrrol-2-ylamine (869287-22-9)

Guidance literature:

With ammonium chloride; In methanol; at 50 ℃; for 3.5h;

DOI:10.1016/j.bmcl.2005.07.076

Reference yield:

(5S)-5-[[(tert-butyldiphenylsilyl)oxy]methyl]pyrrolidin-2-one (132974-83-5) → 5-(tert-butyl-diphenyl-silanyloxymethyl)-4,5-dihydro-3H-pyrrol-2-ylamine (869287-22-9)

Guidance literature:

Multi-step reaction with 3 steps

1: Lawesson's reagent / tetrahydrofuran / 2 h / 20 °C

2: CH₂Cl₂ / 5 h / 20 °C

3: NH₄Cl / methanol / 3.5 h / 50 °C

With Lawessons reagent; ammonium chloride; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.bmcl.2005.07.076

upstream raw materials:

2-(tert-butyl-diphenyl-silanyloxymethyl)-5-methylsulfanyl-3,4-dihydro-2H-pyrrole

(5S)-5-[[(tert-butyldiphenylsilyl)oxy]methyl]pyrrolidin-2-one

(S)-5-[(tert-butyl)-diphenylsilyloxy-methyl]-2-thiopyrrolidinone

tert-butylchlorodiphenylsilane

Downstream raw materials:

{4-[2-(4-fluoro-phenyl)-5-(4-methoxy-benzyloxymethyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl]-pyrimidin-2-yl}-propyl-amine

2-(4-fluoro-phenyl)-5-(4-methoxy-benzyloxymethyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole

(S)-5-((tert-butyldiphenylsilyloxy)methyl)-2-(4-fluorophenyl)-6,7-dihydro-5Hpyrrolo[1,2-a]imidazole

[2-(4-fluoro-phenyl)-3-(2-propylamino-pyrimidin-4-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-5-yl]-methanol

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