1-(6-amino-1,3-benzodioxol-5-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one

Base Information

• Chemical Name: 1-(6-amino-1,3-benzodioxol-5-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
• CAS No.: 421766-44-1
• Molecular Formula: C₁₉H₁₉NO₆
• Molecular Weight: 357.363

Synonyms:1-(6-amino-1,3-benzodioxol-5-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one

Chemical Property of 1-(6-amino-1,3-benzodioxol-5-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one

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Technology Process of 1-(6-amino-1,3-benzodioxol-5-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one

There total 1 articles about 1-(6-amino-1,3-benzodioxol-5-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3,4,5-trimethoxy-benzaldehyde (86-81-7) + 2-amino-4,5-methylenedioxy-acetophenone (28657-75-2) → 1-(6-amino-1,3-benzodioxol-5-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (421766-44-1)

Guidance literature:

With sodium hydroxide; In ethanol; at 59.85 - 69.85 ℃; for 0.25h;

DOI:10.1107/S0108270101018297

Reference yield: 87.0%

cis,trans-2,5-dimethoxytetrahydrofuran (696-59-3) + 1-(6-amino-1,3-benzodioxol-5-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (421766-44-1) → 4-(3,4,5-trimethoxyphenyl)-4,5-dihydro-6H-[1,3]dioxolobenzo[4,5-h]pyrrolo[1,2-a][1]benzazepin-6-one (1087269-68-8)

Guidance literature:

With phosphoric acid; at 70 ℃; for 0.0833333h;

DOI:10.1002/ejoc.200800493

Reference yield: 20.0%

cis,trans-2,5-dimethoxytetrahydrofuran (696-59-3) + 1-(6-amino-1,3-benzodioxol-5-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (421766-44-1) → C23H21NO6 (1087269-50-8) + 4-(3,4,5-trimethoxyphenyl)-4,5-dihydro-6H-[1,3]dioxolobenzo[4,5-h]pyrrolo[1,2-a][1]benzazepin-6-one (1087269-68-8)

Guidance literature:

With acetic acid; In toluene; for 2h; Reflux;

DOI:10.1002/ejoc.200800493

upstream raw materials:

3,4,5-trimethoxy-benzaldehyde

2-amino-4,5-methylenedioxy-acetophenone

Downstream raw materials:

C₂₃H₂₁NO₆

4-(3,4,5-trimethoxyphenyl)-4,5-dihydro-6H-[1,3]dioxolobenzo[4,5-h]pyrrolo[1,2-a][1]benzazepin-6-one

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