(S)-3-(5-(aminomethyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine

Base Information

Chemical Name:(S)-3-(5-(aminomethyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine
CAS No.:1585941-33-8
Molecular Formula:C₂₀H₂₅FN₂O
Molecular Weight:328.43
Hs Code.:

Synonyms:(S)-3-(5-(aminomethyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine

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Chemical Property of (S)-3-(5-(aminomethyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine

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Technology Process of (S)-3-(5-(aminomethyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine

There total 1 articles about (S)-3-(5-(aminomethyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128196-01-0
escitalopram

: 1585941-33-8
(S)-3-(5-(aminomethyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 5h; Reflux;
DOI:10.1021/ml5000806

Reference yield: 97.0%

: 1585941-33-8
(S)-3-(5-(aminomethyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine

: C₁₇H₁₂ClNO₃

: (S)-N-((1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl)methyl)-3-(4-(1,3-dioxoisoindolin-2-yl)phenyl)propanamide

Guidance literature:: With sodium hydroxide; In chloroform; water; at 0 - 20 ℃; for 3h;
DOI:10.1021/acs.jmedchem.5b00682

Reference yield: 81.0%

: 1236196-77-2
propargyloxybenzophenone carboxylic acid

: 1585941-33-8
(S)-3-(5-(aminomethyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine

: (S)-N-((1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl)methyl)-4-(4-(prop-2-yn-1-yloxy)benzoyl)benzamide

Guidance literature:: propargyloxybenzophenone carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 ℃; for 1h; Darkness; Inert atmosphere;

(S)-3-(5-(aminomethyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2018.09.029