4-iodo-5-[methoxy(4-methoxyphenyl)methyl]-1-methyl-1H-imidazole

Base Information

• Chemical Name: 4-iodo-5-[methoxy(4-methoxyphenyl)methyl]-1-methyl-1H-imidazole
• CAS No.: 1197054-83-3
• Molecular Formula: C₁₃H₁₅IN₂O₂
• Molecular Weight: 358.179
• Mol file: 1197054-83-3.mol

Synonyms:4-iodo-5-[methoxy(4-methoxyphenyl)methyl]-1-methyl-1H-imidazole

Chemical Property of 4-iodo-5-[methoxy(4-methoxyphenyl)methyl]-1-methyl-1H-imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-iodo-5-[methoxy(4-methoxyphenyl)methyl]-1-methyl-1H-imidazole

There total 1 articles about 4-iodo-5-[methoxy(4-methoxyphenyl)methyl]-1-methyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(4-iodo-1-methyl-1H-imidazol-5-yl)(4-methoxyphenyl)methanol (1197054-82-2) + methyl iodide (74-88-4) → 4-iodo-5-[methoxy(4-methoxyphenyl)methyl]-1-methyl-1H-imidazole (1197054-83-3)

Guidance literature:

(4-iodo-1-methyl-1H-imidazol-5-yl)(4-methoxyphenyl)methanol; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 - 60 ℃; for 2.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1055/s-0029-1216929

Reference yield: 48.0%

4-iodo-5-[methoxy(4-methoxyphenyl)methyl]-1-methyl-1H-imidazole (1197054-83-3) + p-[(tert-butyldimethylsilyl)oxy]benzaldehyde (120743-99-9) → 5-[methoxy(4-methoxyphenyl)methyl]-1-methyl-1H-imidazole (1197054-84-4) + [4-(tert-butyldimethylsilyloxy)phenyl]-{5-[methoxy(4-methoxyphenyl)methyl]-1-methyl-1H-imidazol-4-yl}methanol (1197054-88-8)

Guidance literature:

4-iodo-5-[methoxy(4-methoxyphenyl)methyl]-1-methyl-1H-imidazole; With ethylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 20 ℃; for 0.333333h; Inert atmosphere;

p-[(tert-butyldimethylsilyl)oxy]benzaldehyde; In tetrahydrofuran; diethyl ether; at 20 ℃; for 45h; optical yield given as %de; Inert atmosphere; Reflux;

DOI:10.1055/s-0029-1216929

Reference yield: 35.0%

4-iodo-5-[methoxy(4-methoxyphenyl)methyl]-1-methyl-1H-imidazole (1197054-83-3) + (4-(bromomethyl)phenoxy) (tert-butyl) dimethylsilane (120506-39-0) → 1-[4-(tert-butyldimethylsilyloxy)benzyl]-4-[methoxy(4-methoxyphenyl)methyl]-3-methyl-3H-imidazol-1-ium bromide (1197054-85-5)

Guidance literature:

4-iodo-5-[methoxy(4-methoxyphenyl)methyl]-1-methyl-1H-imidazole; With ethylmagnesium bromide; In diethyl ether; dichloromethane; at 20 ℃; for 0.75h; Inert atmosphere;

With copper(I) cyanide di(lithium chloride); In diethyl ether; dichloromethane; Inert atmosphere;

(4-(bromomethyl)phenoxy)(tert-butyl)dimethylsilane; In diethyl ether; dichloromethane; at 20 ℃; for 15h; Inert atmosphere;

DOI:10.1055/s-0029-1216929

upstream raw materials:

(4-iodo-1-methyl-1H-imidazol-5-yl)(4-methoxyphenyl)methanol

methyl iodide

Downstream raw materials:

(4-hydroxyphenyl)-{5-[methoxy(4-methoxyphenyl)methyl]-1-methyl-1H-imidazol-4-yl}methanone

[4-(tert-butyldimethylsilyloxy)phenyl]-{5-[methoxy(4-methoxyphenyl)methyl]-1-methyl-1H-imidazol-4-yl}methanone

5-[methoxy(4-methoxyphenyl)methyl]-1-methyl-1H-imidazole

[4-(tert-butyldimethylsilyloxy)phenyl]-{5-[methoxy(4-methoxyphenyl)methyl]-1-methyl-1H-imidazol-4-yl}methanol