3-(tert-butyldimethylsiloxy)ethyl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole

Base Information

Chemical Name:3-(tert-butyldimethylsiloxy)ethyl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole
CAS No.:873657-15-9
Molecular Formula:C₂₅H₃₂ClNO₃Si
Molecular Weight:458.072
Hs Code.:

Synonyms:3-(tert-butyldimethylsiloxy)ethyl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole

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Chemical Property of 3-(tert-butyldimethylsiloxy)ethyl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole

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Technology Process of 3-(tert-butyldimethylsiloxy)ethyl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole

There total 3 articles about 3-(tert-butyldimethylsiloxy)ethyl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 873657-14-8
N-(4-chlorobenzoyl)-2-iodo-4-methoxyaniline

: 1-(tert-buyldimethylsiloxy)-3-(tributylstannyl)-3,4-pentadiene

: 873657-15-9
3-(tert-butyldimethylsiloxy)ethyl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole

Guidance literature:: With copper(l) iodide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; trifuran-2-yl-phosphane; tetrabutyl-ammonium chloride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/ol052179u

Reference yield:

: 122-01-0
4-chloro-benzoyl chloride

: 873657-15-9
3-(tert-butyldimethylsiloxy)ethyl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / pyridine / 1 h / 80 °C

2: 54 percent / tri-2-furylphosphine; CuI; Pd₂(dba)3 / Bu₄NCl / dimethylformamide / 2 h / 20 °C

With pyridine; copper(l) iodide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; trifuran-2-yl-phosphane; tetrabutyl-ammonium chloride; In N,N-dimethyl-formamide;
DOI:10.1021/ol052179u

Reference yield:

: 191348-14-8
2-iodo-4-methoxylaniline

: 873657-15-9
3-(tert-butyldimethylsiloxy)ethyl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / pyridine / 1 h / 80 °C

2: 54 percent / tri-2-furylphosphine; CuI; Pd₂(dba)3 / Bu₄NCl / dimethylformamide / 2 h / 20 °C

With pyridine; copper(l) iodide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; trifuran-2-yl-phosphane; tetrabutyl-ammonium chloride; In N,N-dimethyl-formamide;
DOI:10.1021/ol052179u