(4-chlorophenyl)(3-(2-hydroxyethyl)-5-methoxy-2-methyl-1H-indol-1-yl)methanone

Base Information

Chemical Name:(4-chlorophenyl)(3-(2-hydroxyethyl)-5-methoxy-2-methyl-1H-indol-1-yl)methanone
CAS No.:16130-32-8
Molecular Formula:C₁₉H₁₈ClNO₃
Molecular Weight:343.81
Hs Code.:

Synonyms:(4-chlorophenyl)(3-(2-hydroxyethyl)-5-methoxy-2-methyl-1H-indol-1-yl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4-chlorophenyl)(3-(2-hydroxyethyl)-5-methoxy-2-methyl-1H-indol-1-yl)methanone

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Technology Process of (4-chlorophenyl)(3-(2-hydroxyethyl)-5-methoxy-2-methyl-1H-indol-1-yl)methanone

There total 7 articles about (4-chlorophenyl)(3-(2-hydroxyethyl)-5-methoxy-2-methyl-1H-indol-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 53-86-1
[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

: 16130-32-8
(4-chlorophenyl)(3-(2-hydroxyethyl)-5-methoxy-2-methyl-1H-indol-1-yl)methanone

Guidance literature:: With diborane; In tetrahydrofuran; at 0 ℃; for 120h;
DOI:10.3390/molecules26164928

Reference yield:

: 873657-15-9
3-(tert-butyldimethylsiloxy)ethyl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole

: 16130-32-8
(4-chlorophenyl)(3-(2-hydroxyethyl)-5-methoxy-2-methyl-1H-indol-1-yl)methanone

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃; for 5h;
DOI:10.1021/ol052179u

Reference yield:

: 873657-14-8
N-(4-chlorobenzoyl)-2-iodo-4-methoxyaniline

: 16130-32-8
(4-chlorophenyl)(3-(2-hydroxyethyl)-5-methoxy-2-methyl-1H-indol-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / tri-2-furylphosphine; CuI; Pd₂(dba)3 / Bu₄NCl / dimethylformamide / 2 h / 20 °C

2: TBAF; AcOH / tetrahydrofuran / 5 h / 20 °C

With copper(l) iodide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; trifuran-2-yl-phosphane; tetrabutyl ammonium fluoride; acetic acid; tetrabutyl-ammonium chloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ol052179u