2(5H)-FURANONE, 5-HYDROXY-4-PROPYL-

Base Information

• Chemical Name: 2(5H)-FURANONE, 5-HYDROXY-4-PROPYL-
• CAS No.: 78920-10-2
• Molecular Formula: C7H10 O3
• Molecular Weight: 142.155
• Hs Code.: 2932209090
• Mol file: 78920-10-2.mol

Synonyms:5-hydroxy-4-propylfuran-2(5H)-one

Chemical Property of 2(5H)-FURANONE, 5-HYDROXY-4-PROPYL-

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.508
• Boiling Point: 325.76°C at 760 mmHg
• PKA: 10.04±0.40(Predicted)
• Flash Point: 152.212°C
• PSA: 46.53000
• Density: 1.198g/cm³
• LogP: 0.58810
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Sparingly), Methanol (Slightly)

Purity/Quality:

99.9% ^*data from raw suppliers

5-Hydroxy-4-propylfuran-2(5H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2(5H)-FURANONE, 5-HYDROXY-4-PROPYL-

There total 4 articles about 2(5H)-FURANONE, 5-HYDROXY-4-PROPYL- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.3%

pentanal (110-62-3) + Glyoxilic acid (298-12-4) → 5-hydroxy-4-n-propyl-2,5-dihydrofuran-2-one (78920-10-2)

Guidance literature:

With morpholine; In n-heptane; at 40.1 - 41.7 ℃; for 18h; Industrial scale;

Reference yield: 90.8%

pentanal (110-62-3) → 5-hydroxy-4-n-propyl-2,5-dihydrofuran-2-one (78920-10-2)

Guidance literature:

Glyoxilic acid; With morpholine; In n-heptane; water; at 20 ℃; for 1h;

pentanal; In n-heptane; water; at 43 ℃; for 20h;

With hydrogenchloride; In n-heptane; water; at 20 ℃; for 2h;

Reference yield: 70.0%

pentanal (110-62-3) + 2,2-dihydroxyacetic acid (563-96-2) → 5-hydroxy-4-n-propyl-2,5-dihydrofuran-2-one (78920-10-2)

Guidance literature:

With morpholin hydrochloride; In 1,4-dioxane; water; 1) RT, 1 h, 2) 24 h, reflux;

DOI:10.1021/jo00337a013

upstream raw materials:

5-Ethoxy-4-propyl-5H-furan-2-one

pentanal

2,2-dihydroxyacetic acid

Glyoxilic acid

Downstream raw materials:

brivaracetam

((2S)-2-[(4S)-2-oxo-4-propyltetrahydro-1H-pyrrol-1-yl]butanamide)

5-hydroxy-1-[1-((R)-phenyl)-ethyl]-4-n-propyl-1,5-dihydro-pyrrol-2-one

5-hydroxy-1-[1-((S)-phenyl)-ethyl]-4-n-propyl-1,5-dihydro-pyrrol-2-one

Refernces

• 1、 -. "Intermediate for synthesizing brivaracetam and preparation method thereof". Paragraph 0017-0018. . Retrieved 2021/02/10.
• 2、 -. "ENANTIOSELECTIVE SYNTHESIS OF BRIVARACETAM AND INTERMEDIATES THEREOF". Page/Page column 25; 31; 32. . Retrieved 2020/07/31.