(3S,4R,6S)-6-((E)-(R)-2-Benzenesulfonyl-1,3-dimethyl-hex-4-enyl)-2-(2-chloro-ethoxy)-3-methoxy-tetrahydro-pyran-4-ol

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Chemical Name:(3S,4R,6S)-6-((E)-(R)-2-Benzenesulfonyl-1,3-dimethyl-hex-4-enyl)-2-(2-chloro-ethoxy)-3-methoxy-tetrahydro-pyran-4-ol
CAS No.:82598-95-6
Molecular Formula:C₂₂H₃₃ClO₆S
Molecular Weight:461.019
Hs Code.:

Synonyms:(3S,4R,6S)-6-((E)-(R)-2-Benzenesulfonyl-1,3-dimethyl-hex-4-enyl)-2-(2-chloro-ethoxy)-3-methoxy-tetrahydro-pyran-4-ol

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Chemical Property of (3S,4R,6S)-6-((E)-(R)-2-Benzenesulfonyl-1,3-dimethyl-hex-4-enyl)-2-(2-chloro-ethoxy)-3-methoxy-tetrahydro-pyran-4-ol

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Technology Process of (3S,4R,6S)-6-((E)-(R)-2-Benzenesulfonyl-1,3-dimethyl-hex-4-enyl)-2-(2-chloro-ethoxy)-3-methoxy-tetrahydro-pyran-4-ol

There total 13 articles about (3S,4R,6S)-6-((E)-(R)-2-Benzenesulfonyl-1,3-dimethyl-hex-4-enyl)-2-(2-chloro-ethoxy)-3-methoxy-tetrahydro-pyran-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 82598-94-5
(2S,3S,4R,6S)-6-((E)-(R)-2-Benzenesulfonyl-1,3-dimethyl-hex-4-enyl)-3-methoxy-4-(4-methoxy-benzyloxy)-2-(2-methoxy-ethoxy)-tetrahydro-pyran

: 107-07-3
2-chloro-ethanol

: 82598-95-6
(3S,4R,6S)-6-((E)-(R)-2-Benzenesulfonyl-1,3-dimethyl-hex-4-enyl)-2-(2-chloro-ethoxy)-3-methoxy-tetrahydro-pyran-4-ol

Guidance literature:: With 10-camphorsufonic acid; trimethyl orthoformate; at 80 ℃; for 18h;
DOI:10.1021/jo00193a015

Reference yield:

: 82598-93-4
(1S,2S,4S,6S)-4-((E)-(R)-2-Benzenesulfonyl-1,3-dimethyl-hex-4-enyl)-2-(2-methoxy-ethoxy)-3,7-dioxa-bicyclo[4.1.0]heptane

: 82598-95-6
(3S,4R,6S)-6-((E)-(R)-2-Benzenesulfonyl-1,3-dimethyl-hex-4-enyl)-2-(2-chloro-ethoxy)-3-methoxy-tetrahydro-pyran-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) THF, reflux

2: 10-camphorsulfonic acid, (MeO)3CH / 18 h / 80 °C

With (1S)-10-camphorsulfonic acid; trimethyl orthoformate;
DOI:10.1021/ja00382a065

Reference yield:

: 77890-94-9
(1S,2S,4S,6S)-4-((R)-2-Benzenesulfonyl-1-methyl-ethyl)-2-(2-methoxy-ethoxy)-3,7-dioxa-bicyclo[4.1.0]heptane

: 82598-95-6
(3S,4R,6S)-6-((E)-(R)-2-Benzenesulfonyl-1,3-dimethyl-hex-4-enyl)-2-(2-chloro-ethoxy)-3-methoxy-tetrahydro-pyran-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / n-BuLi

2: 1.) THF, reflux

3: 10-camphorsulfonic acid, (MeO)3CH / 18 h / 80 °C

With n-butyllithium; (1S)-10-camphorsulfonic acid; trimethyl orthoformate;
DOI:10.1021/ja00382a065