4-([1,1'-biphenyl]-4-ylamino)-1-hydroxypyrido[2,3-d]pyrimidin-2(1H)-one

Base Information

Chemical Name:4-([1,1'-biphenyl]-4-ylamino)-1-hydroxypyrido[2,3-d]pyrimidin-2(1H)-one
CAS No.:1312345-12-2
Molecular Formula:C₁₉H₁₄N₄O₂
Molecular Weight:330.346
Hs Code.:

Synonyms:4-([1,1'-biphenyl]-4-ylamino)-1-hydroxypyrido[2,3-d]pyrimidin-2(1H)-one

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Chemical Property of 4-([1,1'-biphenyl]-4-ylamino)-1-hydroxypyrido[2,3-d]pyrimidin-2(1H)-one

Chemical Property:

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Technology Process of 4-([1,1'-biphenyl]-4-ylamino)-1-hydroxypyrido[2,3-d]pyrimidin-2(1H)-one

There total 8 articles about 4-([1,1'-biphenyl]-4-ylamino)-1-hydroxypyrido[2,3-d]pyrimidin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₂₀N₄O₂

: 1312345-12-2
4-([1,1'-biphenyl]-4-ylamino)-1-hydroxypyrido[2,3-d]pyrimidin-2(1H)-one

Guidance literature:: With hydrogen bromide; acetic acid; at 80 ℃; for 6h;
DOI:10.1016/j.ejmech.2014.06.061

Reference yield:

: 1312356-04-9
methyl 2-{[(phenylmethyl)oxy]amino}-3-pyridine carboxylate

: 1312345-12-2
4-([1,1'-biphenyl]-4-ylamino)-1-hydroxypyrido[2,3-d]pyrimidin-2(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: 1,2-dichloro-ethane / 1.5 h / 120 °C / Microwave irradiation

2: sodium methylate / methanol / 0.08 h

3: ammonium cerium (IV) nitrate / acetonitrile; water / 0.5 h / Reflux

4: trichlorophosphate; N-ethyl-N,N-diisopropylamine / 0.75 h / 100 °C

5: N,N-dimethyl-formamide / 2 h / 20 °C

6: acetic acid; hydrogen bromide / 6 h / 80 °C

With ammonium cerium (IV) nitrate; hydrogen bromide; sodium methylate; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2014.06.061

Reference yield:

: 1312356-01-6
2-{[(phenylmethyl)oxy]amino}-3-pyridinecarboxylic acid

: 1312345-12-2
4-([1,1'-biphenyl]-4-ylamino)-1-hydroxypyrido[2,3-d]pyrimidin-2(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid / diethyl ether; methanol; hexane / 0.08 h

2: 1,2-dichloro-ethane / 1.5 h / 120 °C / Microwave irradiation

3: sodium methylate / methanol / 0.08 h

4: ammonium cerium (IV) nitrate / acetonitrile; water / 0.5 h / Reflux

5: trichlorophosphate; N-ethyl-N,N-diisopropylamine / 0.75 h / 100 °C

6: N,N-dimethyl-formamide / 2 h / 20 °C

7: acetic acid; hydrogen bromide / 6 h / 80 °C

With ammonium cerium (IV) nitrate; hydrogen bromide; sodium methylate; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; diethyl ether; hexane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2014.06.061