N-(2,4-difluoro-3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-1,1,2,2,3,3,3-d7-propane-1-sulfonamide

Base Information

Chemical Name:N-(2,4-difluoro-3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-1,1,2,2,3,3,3-d7-propane-1-sulfonamide
CAS No.:1365986-73-7
Molecular Formula:C₂₃H₁₈ClF₂N₃O₃S
Molecular Weight:496.874
Hs Code.:

Synonyms:N-(2,4-difluoro-3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-1,1,2,2,3,3,3-d7-propane-1-sulfonamide

Suppliers and Price of N-(2,4-difluoro-3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-1,1,2,2,3,3,3-d7-propane-1-sulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2,4-difluoro-3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-1,1,2,2,3,3,3-d7-propane-1-sulfonamide

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

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Technology Process of N-(2,4-difluoro-3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-1,1,2,2,3,3,3-d7-propane-1-sulfonamide

There total 3 articles about N-(2,4-difluoro-3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-1,1,2,2,3,3,3-d7-propane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1304096-52-3
N-(3-(5-bromo-1H-pyrrolo[2.3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)-1,1,2,2,3,3,3-heptadeuteropropane-1-sulfonamide

: 1679-18-1
4-Chlorophenylboronic acid

: 1365986-73-7
N-(2,4-difluoro-3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-1,1,2,2,3,3,3-d7-propane-1-sulfonamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; acetonitrile; at 170 ℃; for 15h; Sealed flask;

Reference yield:

: 1304096-62-5
N-(2,4-difluorophenyl)-1,1,2,2,3,3,3-heptadeuteropropane-1-sulfonamide

: 1365986-73-7
N-(2,4-difluoro-3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-1,1,2,2,3,3,3-d7-propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / -78 - 0 °C

1.2: 15 h / 20 °C

2.1: potassium carbonate / water; methanol / 72 h / 20 °C

2.2: pH 7

3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane; water / 2 h / 20 °C

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile; water / 15 h / 170 °C / Sealed flask

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium carbonate; diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water; acetonitrile;

Reference yield:

: 1304096-64-7
N-(2,4-difluoro-3-formylphenyl)-1,1,2,2,3,3,3-heptadeuteropropane-1-sulfonamide

: 1365986-73-7
N-(2,4-difluoro-3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-1,1,2,2,3,3,3-d7-propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / water; methanol / 72 h / 20 °C

1.2: pH 7

2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane; water / 2 h / 20 °C

3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile; water / 15 h / 170 °C / Sealed flask

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; methanol; water; acetonitrile;