2-FLUORO-3-METHYLPHENOL

Base Information

• Chemical Name: 2-FLUORO-3-METHYLPHENOL
• CAS No.: 77772-72-6
• Molecular Formula: C₇H₇FO
• Molecular Weight: 126.13
• Hs Code.: 2908199090
• Mol file: 77772-72-6.mol

Synonyms:2-Fluoro-m-cresol;

Chemical Property of 2-FLUORO-3-METHYLPHENOL

Chemical Property:

• Vapor Pressure: 0.911mmHg at 25°C
• Refractive Index: 1.52
• Boiling Point: 174.199 °C at 760 mmHg
• PKA: 8.82±0.10(Predicted)
• Flash Point: 67.386 °C
• PSA: 20.23000
• Density: 1.164 g/cm³
• LogP: 1.83970
• Storage Temp.: Room temperature.

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-3-methylphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FLUORO-3-METHYLPHENOL

There total 3 articles about 2-FLUORO-3-METHYLPHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.3%

2-tert-butyl-5-methyl-6-fluorophenol → 2-fluoro-3-methylphenol (77772-72-6)

Guidance literature:

With aluminium trichloride; In toluene; at 50 ℃; for 4h;

Reference yield: 23.7%

3-methyl-phenol (108-39-4) → 4-fluoro-3-methylphenol (452-70-0) + 2-fluoro-5-methylphenol (63762-79-8) + 2-fluoro-3-methylphenol (77772-72-6)

Guidance literature:

With fluorine; In various solvent(s); at 0 ℃; for 2h;

DOI:10.1016/S0022-1139(00)85261-6

Reference yield:

2-tert-Butyl-5-methylphenol (88-60-8) → 2-fluoro-3-methylphenol (77772-72-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 60.1 percent / acetyl hypofluorite / CCl₃F / 1 h / -60 - -35 °C

2: 96.3 percent / AlCl₃ / toluene / 4 h / 50 °C

With aluminium trichloride; acetyl hypofluorite; In trichlorofluoromethane; toluene;

upstream raw materials:

3-methyl-phenol

2-tert-Butyl-5-methylphenol

Downstream raw materials:

6-chloro-2-fluoro-4-methoxy-3-methylphenol

2-fluoro-4,4-dimethoxy-3-methylcyclohexa-2,5-dienone

Refernces

• 1、 Misaki, Susumu. "DIRECT FLUORINATION OF PHENOL AND CRESOLS". . p. 159 - 172. Retrieved 2007/10/02.