(3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-6-((2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-4,12,13-trihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione 10-[O-(2-methoxy-phenoxymethyl)-oxime]

Base Information

Chemical Name:(3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-6-((2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-4,12,13-trihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione 10-[O-(2-methoxy-phenoxymethyl)-oxime]
CAS No.:876316-01-7
Molecular Formula:C₃₈H₆₄N₂O₁₂
Molecular Weight:740.932
Hs Code.:

(3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-6-((2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-4,12,13-trihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione 10-[O-(2-methoxy-phenoxymethyl)-oxime]

Synonyms:(3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-6-((2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-4,12,13-trihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione 10-[O-(2-methoxy-phenoxymethyl)-oxime]

Suppliers and Price of (3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-6-((2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-4,12,13-trihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione 10-[O-(2-methoxy-phenoxymethyl)-oxime]

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Chemical Property of (3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-6-((2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-4,12,13-trihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione 10-[O-(2-methoxy-phenoxymethyl)-oxime]

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Technology Process of (3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-6-((2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-4,12,13-trihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione 10-[O-(2-methoxy-phenoxymethyl)-oxime]

There total 10 articles about (3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-6-((2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-4,12,13-trihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione 10-[O-(2-methoxy-phenoxymethyl)-oxime] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 876315-99-0
C₄₆H₇₈N₂O₁₅

: 876316-01-7
(3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-6-((2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-4,12,13-trihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione 10-[O-(2-methoxy-phenoxymethyl)-oxime]

Guidance literature:: With hydrogenchloride; at 20 ℃;
DOI:10.1016/j.bmcl.2005.10.045

Reference yield:

: 91-16-7
1,2-dimethoxybenzene

: 876316-01-7
(3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-6-((2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-4,12,13-trihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione 10-[O-(2-methoxy-phenoxymethyl)-oxime]

Guidance literature:: Multi-step reaction with 8 steps

1: 82 percent / PCl₅; benzoyl peroxide / CCl₄ / Heating

2: 66 percent / K₂CO₃ / dimethylformamide

3: NH₂NH₂ / ethanol / Heating

4: 43 percent / methanol

5: 98 percent / NH₄Cl / dimethylformamide / 50 °C

6: 74 percent / KOH / dimethylsulfoxide; tetrahydrofuran / 2 h / 0 °C

7: 91 percent / aq. HCOOH / ethanol

8: 82 percent / aq. HCl / 20 °C

With hydrogenchloride; potassium hydroxide; formic acid; phosphorus pentachloride; potassium carbonate; ammonium chloride; hydrazine; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.10.045

Reference yield:

: 79263-62-0
guaiacylmethyl chloride

: 876316-01-7
(3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-6-((2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-4,12,13-trihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione 10-[O-(2-methoxy-phenoxymethyl)-oxime]

Guidance literature:: Multi-step reaction with 7 steps

1: 66 percent / K₂CO₃ / dimethylformamide

2: NH₂NH₂ / ethanol / Heating

3: 43 percent / methanol

4: 98 percent / NH₄Cl / dimethylformamide / 50 °C

5: 74 percent / KOH / dimethylsulfoxide; tetrahydrofuran / 2 h / 0 °C

6: 91 percent / aq. HCOOH / ethanol

7: 82 percent / aq. HCl / 20 °C

With hydrogenchloride; potassium hydroxide; formic acid; potassium carbonate; ammonium chloride; hydrazine; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.10.045