N-[(2R,3S)-1-(2-Hydroxy-2-phenyl-ethyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide

Base Information

Chemical Name:N-[(2R,3S)-1-(2-Hydroxy-2-phenyl-ethyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide
CAS No.:101067-71-4
Molecular Formula:C₂₆H₂₆N₂O₅
Molecular Weight:446.503
Hs Code.:

Synonyms:N-[(2R,3S)-1-(2-Hydroxy-2-phenyl-ethyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide

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Chemical Property of N-[(2R,3S)-1-(2-Hydroxy-2-phenyl-ethyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide

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Technology Process of N-[(2R,3S)-1-(2-Hydroxy-2-phenyl-ethyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide

There total 4 articles about N-[(2R,3S)-1-(2-Hydroxy-2-phenyl-ethyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (Z)-3-Amino-3-[(2R,3S)-1-(2-hydroxy-2-phenyl-ethyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-3-yl]-acrylic acid methyl ester

: 101067-71-4
N-[(2R,3S)-1-(2-Hydroxy-2-phenyl-ethyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) HCl 6N, 2.) NaOH

2: triethylamine / CH₂Cl₂

With hydrogenchloride; sodium hydroxide; triethylamine; In dichloromethane;
DOI:10.1016/S0040-4039(00)99001-4

Reference yield:

: 101067-65-6
[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-(2-phenyl-2-trimethylsilanyloxy-ethyl)-amine

: 101067-71-4
N-[(2R,3S)-1-(2-Hydroxy-2-phenyl-ethyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) phenyl dichlorophosphate, triethylamine, 2.) water / 1.) CH₂Cl₂

2: 1.) HCl 6N, 2.) NaOH

3: triethylamine / CH₂Cl₂

With hydrogenchloride; sodium hydroxide; water; O-phenyl phosphorodichloridate; triethylamine; In dichloromethane;
DOI:10.1016/S0040-4039(00)99001-4