N-(phenoxyacetyl)glycine

Base Information

• Chemical Name: N-(phenoxyacetyl)glycine
• CAS No.: 14231-45-9
• Molecular Formula: C10H11 N O4
• Molecular Weight: 209.202
• Hs Code.: 2924299090
• NSC Number: 174212
• DSSTox Substance ID: DTXSID20306137
• Nikkaji Number: J1.834.222G
• Wikidata: Q82053072
• Mol file: 14231-45-9.mol

Synonyms:N-(phenoxyacetyl)glycine;14231-45-9;[(phenoxyacetyl)amino]acetic acid;2-(2-phenoxyacetamido)acetic acid;2-[(2-phenoxyacetyl)amino]acetic acid;MFCD00667226;(PHENOXYACETYL)AMINO]ACETIC ACID;phenoxyacetylglycine;Phenoxyacetyl glycine;NSC174212;Oprea1_622817;SCHEMBL7821754;2-(2-phenoxyacetamido)aceticacid;DTXSID20306137;MYTAKEVMLYCYIE-UHFFFAOYSA-N;HMS1773J14;BBL002332;STK115252;AKOS000117162;NSC-174212;VS-01046;CS-0307823;FT-0683658;EN300-08125;J-502692;Z57044269

Chemical Property of N-(phenoxyacetyl)glycine

Chemical Property:

• Vapor Pressure: 8.52E-11mmHg at 25°C
• Boiling Point: 499.5°Cat760mmHg
• Flash Point: 255.9°C
• PSA: 75.63000
• Density: 1.279g/cm³
• LogP: 0.65710
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 209.06880783
• Heavy Atom Count: 15
• Complexity: 224

Purity/Quality:

98%min ^*data from raw suppliers

N-(Phenoxyacetyl)glycine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)OCC(=O)NCC(=O)O

Technology Process of N-(phenoxyacetyl)glycine

There total 5 articles about N-(phenoxyacetyl)glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

Phenoxyacetyl chloride (701-99-5) + glycine (56-40-6,18875-39-3,25718-94-9) → N-(phenoxy-acetyl)glycine (14231-45-9)

Guidance literature:

sodium hydroxide; In water;

Reference yield: 53.0%

(2-Phenoxy-acetylamino)-acetic acid tert-butyl ester → N-(phenoxy-acetyl)glycine (14231-45-9)

Guidance literature:

With lithium iodide; In ethyl acetate; for 23h; Heating;

DOI:10.1016/S0040-4039(00)77156-5

Reference yield:

(2-Phenoxy-acetylamino)-acetic acid 4-nitro-benzyl ester → N-(phenoxy-acetyl)glycine (14231-45-9)

Guidance literature:

With lithium iodide; In ethyl acetate; for 24h; Yield given; Heating;

DOI:10.1016/S0040-4039(00)77156-5

upstream raw materials:

Phenoxyacetyl chloride

glycine

Downstream raw materials:

N-[(3S,4R)-1-(2-Hydroxy-2-phenyl-ethyl)-2-oxo-4-phenyl-azetidin-3-yl]-2-phenoxy-acetamide

N-[(2R,3S)-1-(2-Hydroxy-2-phenyl-ethyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide

2-methylphenoxy-4-(p-bis(β-cyanoethylamino)benzylidene)-5-oxazolone

N-phenoxyacetyl-glycine 4-nitro-phenyl ester

Refernces

• 1、 Fisher, Jack W.,Trinkle, Kristina L.. "Iodide Dealkylation of Benzyl, PMB, PNB, and t-Butyl N-Acyl Amino Acid Esters via lithium Ion Coordination". . p. 2505 - 2508. Retrieved 2007/10/02.
• 2、 -. "7-oxabicycloheptane substituted hydroxamic acid prostaglandin analogs". . . Retrieved 2008/06/13.