14-O-{1-[(3-chlorophenyl)ureido]-2-methylpropan-2-ylthioacetyl}mutilin

Base Information

• Chemical Name: 14-O-{1-[(3-chlorophenyl)ureido]-2-methylpropan-2-ylthioacetyl}mutilin
• CAS No.: 1430847-69-0
• Molecular Formula: C₃₃H₄₇ClN₂O₅S
• Molecular Weight: 619.266
• Mol file: 1430847-69-0.mol

Synonyms:14-O-{1-[(3-chlorophenyl)ureido]-2-methylpropan-2-ylthioacetyl}mutilin

Chemical Property of 14-O-{1-[(3-chlorophenyl)ureido]-2-methylpropan-2-ylthioacetyl}mutilin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 14-O-{1-[(3-chlorophenyl)ureido]-2-methylpropan-2-ylthioacetyl}mutilin

There total 4 articles about 14-O-{1-[(3-chlorophenyl)ureido]-2-methylpropan-2-ylthioacetyl}mutilin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

14-O-[(1-amino-2-methylpropane-2-yl)thioacetyl]mutilin (133787-61-8) + N-(3-chlorophenyl)-2,2,2,-trichloroacetamide (3004-73-7) → 14-O-{1-[(3-chlorophenyl)ureido]-2-methylpropan-2-ylthioacetyl}mutilin (1430847-69-0)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 80 ℃;

DOI:10.2174/1570180811310030005

Reference yield:

pleuromutilin tosylate (31716-01-5) → 14-O-{1-[(3-chlorophenyl)ureido]-2-methylpropan-2-ylthioacetyl}mutilin (1430847-69-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethanol; sodium / 0.5 h / -5 °C

1.2: 2 h / 0 - 5 °C

2.1: potassium carbonate / dimethyl sulfoxide / 80 °C

With ethanol; sodium; potassium carbonate; In dimethyl sulfoxide;

DOI:10.2174/1570180811310030005

Reference yield:

pleuromutilin → 14-O-{1-[(3-chlorophenyl)ureido]-2-methylpropan-2-ylthioacetyl}mutilin (1430847-69-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine; pyridine / 1,2-dichloro-ethane / 20 h / 10 - 15 °C

2.1: ethanol; sodium / 0.5 h / -5 °C

2.2: 2 h / 0 - 5 °C

3.1: potassium carbonate / dimethyl sulfoxide / 80 °C

With pyridine; ethanol; sodium; potassium carbonate; triethylamine; In dimethyl sulfoxide; 1,2-dichloro-ethane;

DOI:10.2174/1570180811310030005

upstream raw materials:

14-O-[(1-amino-2-methylpropane-2-yl)thioacetyl]mutilin

N-(3-chlorophenyl)-2,2,2,-trichloroacetamide

3-chloro-aniline

pleuromutilin tosylate