trans-[4-(2-{4-[2-tert-butyl-6-(2-methoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]carbamic acid tert-butyl ester

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Chemical Name:trans-[4-(2-{4-[2-tert-butyl-6-(2-methoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]carbamic acid tert-butyl ester
CAS No.:1607474-28-1
Molecular Formula:C₂₈H₄₉N₅O₃
Molecular Weight:503.729
Hs Code.:

Synonyms:trans-[4-(2-{4-[2-tert-butyl-6-(2-methoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]carbamic acid tert-butyl ester

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Chemical Property of trans-[4-(2-{4-[2-tert-butyl-6-(2-methoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]carbamic acid tert-butyl ester

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Technology Process of trans-[4-(2-{4-[2-tert-butyl-6-(2-methoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]carbamic acid tert-butyl ester

There total 4 articles about trans-[4-(2-{4-[2-tert-butyl-6-(2-methoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1607474-23-6
2-tert-butyl-4-(2-methoxyethyl)-6-piperazin-1-ylpyrimidine

: 215790-29-7
trans-2-(1-(4-(N-tert-butoxycarbonyl)amino)cyclohexyl)acetaldehyde

: 1607474-28-1
trans-[4-(2-{4-[2-tert-butyl-6-(2-methoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]carbamic acid tert-butyl ester

Guidance literature:: 2-tert-butyl-4-(2-methoxyethyl)-6-piperazin-1-ylpyrimidine; trans-2-(1-(4-(N-tert-butoxycarbonyl)amino)cyclohexyl)acetaldehyde; With acetic acid; In dichloromethane; at 20 ℃; for 0.166667h;

With sodium tris(acetoxy)borohydride; In dichloromethane; for 4h;

Reference yield:

: 1607474-25-8
2-tert-butyl-4-chloro-6-(2-methoxyethyl)pyrimidine

: 1607474-28-1
trans-[4-(2-{4-[2-tert-butyl-6-(2-methoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 3 h / Reflux

2.1: acetic acid / dichloromethane / 0.17 h / 20 °C

2.2: 4 h

With acetic acid; In ethanol; dichloromethane;

Reference yield:

: 1607474-24-7
2-tert-butyl-6-(2-methoxyethyl)pyrimidin-4-ol

: 1607474-28-1
trans-[4-(2-{4-[2-tert-butyl-6-(2-methoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / toluene; N,N-dimethyl-formamide / 3 h / 20 °C / Cooling with ice

2.1: ethanol / 3 h / Reflux

3.1: acetic acid / dichloromethane / 0.17 h / 20 °C

3.2: 4 h

With acetic acid; trichlorophosphate; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;