trans-N-[4-(2-{4-[2-tert-butyl-6-(2-methoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]acetamide

Base Information

Chemical Name:trans-N-[4-(2-{4-[2-tert-butyl-6-(2-methoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]acetamide
CAS No.:1607474-27-0
Molecular Formula:C₂₅H₄₃N₅O₂
Molecular Weight:445.649
Hs Code.:

Synonyms:trans-N-[4-(2-{4-[2-tert-butyl-6-(2-methoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]acetamide

Suppliers and Price of trans-N-[4-(2-{4-[2-tert-butyl-6-(2-methoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of trans-N-[4-(2-{4-[2-tert-butyl-6-(2-methoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]acetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of trans-N-[4-(2-{4-[2-tert-butyl-6-(2-methoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]acetamide

There total 6 articles about trans-N-[4-(2-{4-[2-tert-butyl-6-(2-methoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.6%

: 1607474-29-2
trans-4-(2-{4-[2-tert-butyl-6-(2-methoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexylamine

: 75-36-5
acetyl chloride

: 1607474-27-0
trans-N-[4-(2-{4-[2-tert-butyl-6-(2-methoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]acetamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 1607474-25-8
2-tert-butyl-4-chloro-6-(2-methoxyethyl)pyrimidine

: 1607474-27-0
trans-N-[4-(2-{4-[2-tert-butyl-6-(2-methoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 3 h / Reflux

2.1: acetic acid / dichloromethane / 0.17 h / 20 °C

2.2: 4 h

3.1: hydrogenchloride / methanol; water / 16 h / 25 °C

4.1: triethylamine / dichloromethane / 3 h / 20 °C

With hydrogenchloride; acetic acid; triethylamine; In methanol; ethanol; dichloromethane; water;

Reference yield:

: 1607474-28-1
trans-[4-(2-{4-[2-tert-butyl-6-(2-methoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]carbamic acid tert-butyl ester

: 1607474-27-0
trans-N-[4-(2-{4-[2-tert-butyl-6-(2-methoxyethyl)pyrimidin-4-yl]piperazin-1-yl}ethyl)cyclohexyl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / methanol; water / 16 h / 25 °C

2: triethylamine / dichloromethane / 3 h / 20 °C

With hydrogenchloride; triethylamine; In methanol; dichloromethane; water;