112695-36-0

Upstream product

• 98-88-4 benzoyl chloride 
• 123369-29-9 methyl 3-deoxy-3-fluoro-β-D-ribofuranoside 
• 532-32-1 sodium benzoate 
• 551929-56-7 Toluene-4-sulfonic acid (2R,3R,4R,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-fluoro-2-methoxy-tetrahydro-furan-3-yl ester 
• 237410-10-5 ((2R,3S,4S,5R)-3-fluoro-4-hydroxy-5-methoxytetrahydrofuran-2-yl)methyl benzoate 
• 43168-73-6 methyl 2,3-anhydro-β-D-lyxofuranoside 
• 28867-47-2 methyl 5-O-benzyl-3-fluoro-3-deoxy-β-D-arabino-furanoside 
• 29024-87-1 methyl 5-O-benzyl-2,3-anhydro-β-D-lyxofuranoside 
• 124939-88-4 methyl 5-O-benzyl-2-O-benzoyl-3-fluoro-3-deoxy-β-D-ribofuranoside 
• 126716-24-3 methyl 5-O-benzyl-2-O-tosyl-3-fluoro-3-deoxy-β-D-arabino-furanoside 
• 20881-04-3 1,2,3,5-di-O-isopropylidene-D-xylofuranose 
• 112668-61-8 Trifluoro-methanesulfonic acid (2R,3S,4R,5R)-4-benzyloxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-methoxy-tetrahydro-furan-3-yl ester 
• 112668-55-0 methyl 2-O-benzyl-5-O-t-butyldimethylsilyl-β-D-xylofuranoside 
• 51755-01-2 methyl 3-O-benzyl-3,5-O-isopropylidene-β-D-xylofuranoside 

Downstream Products

• 123484-12-8 ((2R,3R,4S)-5-acetoxy-4-(benzoyloxy)-3-fluorotetrahydrofuran-2-yl)methyl benzoate 
• 230632-62-9 ((2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-4-(benzoyloxy)-3-fluorotetrahydrofuran-2-yl)methyl benzoate 
• 75059-22-2 (2R,3S,4S,5R)-2-(6-amino-9H-purine-9-yl)-4-fluoro-5-(hydroxymethyl)tetrahydrofuran-3-ol 
• 123402-20-0 3'-deoxy-3'-fluorocytidine 
• 123402-21-1 2-amino-9-((2R,3S,4S,5R)-4-fluoro-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purine-6-one 
• 133776-13-3 C₂₃H₂₀FN₃O₆ 
• 112668-58-3 1-(2,5-di-O-benzoyl-3-deoxy-3-fluoro-β-D-ribofuranosyl)uracil 
• 133776-12-2 C₂₃H₁₉FN₂O₇ 
• 133776-14-4 C₂₆H₂₂FN₅O₇ 
• 112668-60-7 N6-benzoyl-9-(2'-O-benzoyl-3'-deoxy-3'-fluoro-β-D-ribofuranosyl)adenine 
• 133776-15-5 C₃₆H₄₂FN₅O₇ 
• 133776-16-6 C₃₆H₄₂FN₅O₇ 
• 25526-93-6 alovudine 
• 152711-06-3 Benzoic acid (2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 

Relevant academic research and scientific papers

Oxidation-reduction sequence for the synthesis of peracylated fluorodeoxy pentofuranosides

Oxidation of 1a with DMSO-acetic or trifluoroacetic anhydride led to the formation of a mixture of epimeric gem-diols 2 and 3 in the ratios of ?3:1 and ?7:1, respectively. Reduction of this mixture with NaBH4 followed by benzoylation and chroma

CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS

The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

Design, synthesis and binding affinity of 3′-fluoro analogues of Cl-IB-MECA as adenosine A3 receptor ligands

Several 3′-fluoro analogues, 1a, 1b, and 1c of selective and potent adenosine A3 receptor agonist, Cl-IB-MECA were synthesized from D-xylose via highly regioselective opening of lyxo-epoxides, 8a and 8b with fluoride anion. Compared to the high binding affinity of Cl-IB-MECA to the A3 adenosine receptor, the corresponding 3′-fluoro derivative showed remarkably decreased binding affinity, indicating that 3′-hydroxyl group acts as hydrogen bonding acceptor, not hydrogen bonding donor like fluorine atom in binding to the A3 adenosine receptor.

Design and synthesis of A3 adenosine receptor ligands, 3′-fluoro analogues of Cl-IB-MECA

Synthesis of 3′-deoxy-3′-fluoro-N6-substituted adenosines as bioisosteres of Cl-IB-MECA and their binding affinities to A 3 adenosine receptor are described.

Synthesis and antiviral and cytostatic properties of 3'-deoxy-3'-fluoro- and 2'-azido-3'-fluoro-2',3'-dideoxy-D-ribofuranosides of natural heterocyclic bases

A series of 3'-deoxy-3'-fluoro- and 2'-azido-2',3'-dideoxy-3'-fluoro-D-ribofuranosides of natural heterocyclic bases have been synthesized with the use of universal carbohydrate precursors, viz., 1-O-acetyl-2,5-di-O-benzoyl-3-deoxy-3-fluoro-D-ribofuranose