[(1S,2S,3S)-2-(2-Benzyloxy-ethyl)-3-tert-butoxy-2-methyl-6-methylene-cyclohexyl]-methanol

Base Information

Chemical Name:[(1S,2S,3S)-2-(2-Benzyloxy-ethyl)-3-tert-butoxy-2-methyl-6-methylene-cyclohexyl]-methanol
CAS No.:228556-23-8
Molecular Formula:C₂₂H₃₄O₃
Molecular Weight:346.51
Hs Code.:

Synonyms:[(1S,2S,3S)-2-(2-Benzyloxy-ethyl)-3-tert-butoxy-2-methyl-6-methylene-cyclohexyl]-methanol

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Chemical Property of [(1S,2S,3S)-2-(2-Benzyloxy-ethyl)-3-tert-butoxy-2-methyl-6-methylene-cyclohexyl]-methanol

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Technology Process of [(1S,2S,3S)-2-(2-Benzyloxy-ethyl)-3-tert-butoxy-2-methyl-6-methylene-cyclohexyl]-methanol

There total 7 articles about [(1S,2S,3S)-2-(2-Benzyloxy-ethyl)-3-tert-butoxy-2-methyl-6-methylene-cyclohexyl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 219136-68-2
[2-(2-benzyloxy-ethyl)-3-tert-butoxy-2-methyl-6-methylene-cyclohexylmethoxy]-tert-butyl-dimethyl-silane

: 228556-23-8
[(1S,2S,3S)-2-(2-Benzyloxy-ethyl)-3-tert-butoxy-2-methyl-6-methylene-cyclohexyl]-methanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 5h; Ambient temperature;
DOI:10.1016/S0957-4166(99)00062-2

Reference yield:

: 100-39-0
benzyl bromide

: 228556-23-8
[(1S,2S,3S)-2-(2-Benzyloxy-ethyl)-3-tert-butoxy-2-methyl-6-methylene-cyclohexyl]-methanol

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH / 1.) DMF, 0.5 h, 2.) DMF, 0 deg C, 20 h

2: 5 percent aq. HCl / tetrahydrofuran / 4 h / Ambient temperature

3: DMAP / CH₂Cl₂ / 1.5 h / 0 - 20 °C

4: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 30 min, 2.) CH₂Cl₂, 0 deg C

5: 50 percent / tetrahydrofuran / 0.67 h / Ambient temperature

6: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 5 h / Ambient temperature

With hydrogenchloride; dmap; oxalyl dichloride; tetrabutyl ammonium fluoride; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0957-4166(99)00062-2

Reference yield:

: 155095-85-5
2-((4aS,5S,6S,8aS)-6-tert-Butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxin-5-yl)-ethanol

: 228556-23-8
[(1S,2S,3S)-2-(2-Benzyloxy-ethyl)-3-tert-butoxy-2-methyl-6-methylene-cyclohexyl]-methanol

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH / 1.) DMF, 0.5 h, 2.) DMF, 0 deg C, 20 h

2: 5 percent aq. HCl / tetrahydrofuran / 4 h / Ambient temperature

3: DMAP / CH₂Cl₂ / 1.5 h / 0 - 20 °C

4: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 30 min, 2.) CH₂Cl₂, 0 deg C

5: 50 percent / tetrahydrofuran / 0.67 h / Ambient temperature

6: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 5 h / Ambient temperature

With hydrogenchloride; dmap; oxalyl dichloride; tetrabutyl ammonium fluoride; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0957-4166(99)00062-2