5-METHYLSULFANYL-1H-INDOLE

Base Information

• Chemical Name: 5-METHYLSULFANYL-1H-INDOLE
• CAS No.: 77248-65-8
• Molecular Formula: C9H9NS
• Molecular Weight: 163.243
• Hs Code.: 2933990090
• Mol file: 77248-65-8.mol

Synonyms:5-(Methylthio)-1H-indole;5-(Methylthio)indole;

Chemical Property of 5-METHYLSULFANYL-1H-INDOLE

Chemical Property:

• Vapor Pressure: 0.000249mmHg at 25°C
• Refractive Index: 1.682
• Boiling Point: 334.4 °C at 760 mmHg
• PKA: 16.63±0.30(Predicted)
• Flash Point: 156 °C
• PSA: 41.09000
• Density: 1.21 g/cm³
• LogP: 2.88980

Purity/Quality:

98%min ^*data from raw suppliers

5-Methylthio-indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHYLSULFANYL-1H-INDOLE

There total 4 articles about 5-METHYLSULFANYL-1H-INDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

5-bromo-1H-indole (10075-50-0) → 5-methylthio-1H-indole (77248-65-8)

Guidance literature:

With pyridine; quinoline; for 5h; Heating;

DOI:10.1016/0223-5234(87)90172-3

Reference yield:

5-iodo-1H-indole (16066-91-4) + Dimethyldisulphide (624-92-0) → 5-methylthio-1H-indole (77248-65-8)

Guidance literature:

5-iodo-1H-indole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

Dimethyldisulphide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1h; Inert atmosphere;

Reference yield:

5-bromo-1H-indole (10075-50-0) → 5-methylthio-1H-indole (77248-65-8)

Guidance literature:

With pyridine; hydrogenchloride; In ethyl acetate;

upstream raw materials:

5-bromo-1H-indole

Dimethyldisulphide

5-iodo-1H-indole

Downstream raw materials:

5-(methylthio)indoline

1-(p-toluenesulfonyl)-5-methylsulfonylindole

1-(p-toluenesulfonyl)-5-methylsulfinylindole

N-methyl-5-methylthiotryptamine

Refernces

• 1、 Yang, Youhua,Martin, Arnold R.,Nelson, David L.,Regan, John. "SYNTHESIS OF SOME 5-SUBSTITUTED INDOLES". . p. 1169 - 1175. Retrieved 2007/10/02.
• 2、 -. "Antipsychotic tetrahydropyridinyl-indoles, compositions and method of use". . . Retrieved 2008/06/13.