4-(2-(4-fluorophenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one

Base Information

Chemical Name:4-(2-(4-fluorophenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one
CAS No.:1450824-59-5
Molecular Formula:C₂₀H₁₆ClFO₅
Molecular Weight:390.795
Hs Code.:

Synonyms:4-(2-(4-fluorophenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one

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Chemical Property of 4-(2-(4-fluorophenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one

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Technology Process of 4-(2-(4-fluorophenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one

There total 4 articles about 4-(2-(4-fluorophenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.6%

: 1320275-79-3
C₁₂H₁₀BrClO₃

: Sodium; (4-fluoro-phenyl)-acetate

: 1450824-59-5
4-(2-(4-fluorophenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one

Guidance literature:: In dimethyl sulfoxide; at 20 ℃;
DOI:10.1016/j.bmc.2013.06.066

Reference yield:

: 1878-66-6
4-chlorophenylacetic Acid

: 1450824-59-5
4-(2-(4-fluorophenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water / pH 9 - 10

1.2: 25 °C

2.1: sodium hydride / tetrahydrofuran / 20 °C / Cooling with ice

3.1: triethylamine / acetone / Reflux

4.1: dimethyl sulfoxide / 20 °C

With sodium hydride; triethylamine; sodium hydroxide; In tetrahydrofuran; water; dimethyl sulfoxide; acetone;
DOI:10.1016/j.bmc.2013.06.066

Reference yield:

: 100074-43-9
3-(4-chlorophenyl)-4-hydroxyfuran-2(5H)-one

: 1450824-59-5
4-(2-(4-fluorophenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / acetone / Reflux

2: dimethyl sulfoxide / 20 °C

With triethylamine; In dimethyl sulfoxide; acetone;
DOI:10.1016/j.bmc.2013.06.066