methyl 2-[(benzyloxy)(3-ethoxy-3-oxopropanoyl)amino]-4-(3-bromophenyl)nicotinate

Base Information

• Chemical Name: methyl 2-[(benzyloxy)(3-ethoxy-3-oxopropanoyl)amino]-4-(3-bromophenyl)nicotinate
• CAS No.: 1003933-70-7
• Molecular Formula: C₂₅H₂₃BrN₂O₆
• Molecular Weight: 527.371
• Mol file: 1003933-70-7.mol

Synonyms:methyl 2-[(benzyloxy)(3-ethoxy-3-oxopropanoyl)amino]-4-(3-bromophenyl)nicotinate

Chemical Property of methyl 2-[(benzyloxy)(3-ethoxy-3-oxopropanoyl)amino]-4-(3-bromophenyl)nicotinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-[(benzyloxy)(3-ethoxy-3-oxopropanoyl)amino]-4-(3-bromophenyl)nicotinate

There total 4 articles about methyl 2-[(benzyloxy)(3-ethoxy-3-oxopropanoyl)amino]-4-(3-bromophenyl)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-[(benzyloxy)amino]-4-(3-bromophenyl)nicotinate (1003933-66-1) + ethyl chlorocarbonylacetate (36239-09-5) → methyl 2-[(benzyloxy)(3-ethoxy-3-oxopropanoyl)amino]-4-(3-bromophenyl)nicotinate (1003933-70-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

methyl 2-fluoro-4-iodonicotinate (884494-84-2) → methyl 2-[(benzyloxy)(3-ethoxy-3-oxopropanoyl)amino]-4-(3-bromophenyl)nicotinate (1003933-70-7)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / tetrakis / ethanol; water; toluene / 1.5 h / 110 °C

2: dimethyl sulfoxide / 110 °C

3: triethylamine / dichloromethane / 1 h / 20 °C

With potassium carbonate; triethylamine; tetrakis; In ethanol; dichloromethane; water; dimethyl sulfoxide; toluene;

Reference yield:

(3-bromophenyl)boronic acid (89598-96-9) → methyl 2-[(benzyloxy)(3-ethoxy-3-oxopropanoyl)amino]-4-(3-bromophenyl)nicotinate (1003933-70-7)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / tetrakis / ethanol; water; toluene / 1.5 h / 110 °C

2: dimethyl sulfoxide / 110 °C

3: triethylamine / dichloromethane / 1 h / 20 °C

With potassium carbonate; triethylamine; tetrakis; In ethanol; dichloromethane; water; dimethyl sulfoxide; toluene;

upstream raw materials:

methyl 2-[(benzyloxy)amino]-4-(3-bromophenyl)nicotinate

ethyl chlorocarbonylacetate

methyl 2-fluoro-4-iodonicotinate

methyl 4-(3-bromophenyl)-2-fluoronicotinate

Downstream raw materials:

ethyl 1-(benzyloxy)-5-(3-bromophenyl)-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate

tert-butyl ({3'-[8-(benzyloxy)-5-hydroxy-7-oxo-7,8-dihydro-1,8-naphthyridin-4-yl]biphenyl-3-yl}methyl)carbamate