2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER

Base Information

• Chemical Name: 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER
• CAS No.: 884494-84-2
• Molecular Formula: C7H5 F I N O2
• Molecular Weight: 281.025
• Hs Code.: 2933399090
• Mol file: 884494-84-2.mol

Synonyms:2-Fluoro-4-iodo-3-pyridinecarboxylic acid methyl ester;2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER;methyl 2-fluoro-4-iodonicotinate;

Chemical Property of 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Boiling Point: 286.501oC at 760 mmHg
• PKA: -3.86±0.18(Predicted)
• Flash Point: 127.071oC
• PSA: 39.19000
• Density: 1.914g/cm3
• LogP: 1.61190
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-4-iodonicotinicacidmethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER

There total 5 articles about 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

methanol (67-56-1) + 2-fluoro-4-iodonicotinic acid (884494-51-3) → methyl 2-fluoro-4-iodonicotinate (884494-84-2)

Guidance literature:

With diazomethyl-trimethyl-silane; In diethyl ether; at 25 ℃;

Reference yield:

2-fluoro-4-iodonicotinic acid (884494-51-3) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 2-fluoro-4-iodonicotinate (884494-84-2)

Guidance literature:

In methanol; diethyl ether; hexane; at 10 - 35 ℃; for 3h; Inert atmosphere;

Reference yield:

2-fluoropyridine (372-48-5) → methyl 2-fluoro-4-iodonicotinate (884494-84-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.67 h / -70 °C

1.2: 1.5 h / -70 °C

1.3: 2 h / -70 °C / Inert atmosphere

2.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / tert-butyl alcohol; water / 16 h / 20 °C

3.1: methanol / 16 h / 0 - 20 °C / Inert atmosphere

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; lithium diisopropyl amide; In tetrahydrofuran; methanol; water; tert-butyl alcohol;

upstream raw materials:

2-fluoro-4-iodonicotinic acid

diazomethyl-trimethyl-silane

2-fluoropyridine

[(fluoro-2-iodo-4)pyrid-3-yl]-carboxaldehyde

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