(1,1-dimethylethyl) 4-[[2-butyl-5-(chloromethyl)-1H-imidazol-1-yl]methyl]benzoate

Base Information

• Chemical Name: (1,1-dimethylethyl) 4-[[2-butyl-5-(chloromethyl)-1H-imidazol-1-yl]methyl]benzoate
• CAS No.: 155764-35-5
• Molecular Formula: C₂₀H₂₇ClN₂O₂
• Molecular Weight: 362.9

Synonyms:(1,1-dimethylethyl) 4-[[2-butyl-5-(chloromethyl)-1H-imidazol-1-yl]methyl]benzoate

Chemical Property of (1,1-dimethylethyl) 4-[[2-butyl-5-(chloromethyl)-1H-imidazol-1-yl]methyl]benzoate

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Technology Process of (1,1-dimethylethyl) 4-[[2-butyl-5-(chloromethyl)-1H-imidazol-1-yl]methyl]benzoate

There total 2 articles about (1,1-dimethylethyl) 4-[[2-butyl-5-(chloromethyl)-1H-imidazol-1-yl]methyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(1,1-dimethylethyl) 4-[[2-butyl-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]benzoate (155764-19-5) → (1,1-dimethylethyl) 4-[[2-butyl-5-(chloromethyl)-1H-imidazol-1-yl]methyl]benzoate (155764-35-5)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 - 20 ℃; for 0.0833333h;

DOI:10.1021/jm991050l

Reference yield:

1,1-dimethylethyl 4-<(2-butyl-5-formyl-1H-imidazol-1-yl)methyl>benzoate → (1,1-dimethylethyl) 4-[[2-butyl-5-(chloromethyl)-1H-imidazol-1-yl]methyl]benzoate (155764-35-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / methanol / 0.25 h / 0 °C

2: 97 percent / SOCl₂ / CH₂Cl₂ / 0.08 h / 0 - 20 °C

With sodium tetrahydroborate; thionyl chloride; In methanol; dichloromethane; 1: Reduction / 2: Substitution;

DOI:10.1021/jm991050l

Reference yield: 50.0%

benzyl anthranilate (82185-41-9) + (1,1-dimethylethyl) 4-[[2-butyl-5-(chloromethyl)-1H-imidazol-1-yl]methyl]benzoate (155764-35-5) → (1,1-dimethyl) 4-[[2-butyl-5-[[2-(phenylmethoxycarbonyl)phenyl]aminomethyl]-1H-imidazol-1-yl]methyl]benzoate (155740-70-8)

Guidance literature:

With 2,6-dimethylpyridine; In toluene; for 1h; Heating;

DOI:10.1021/jm991050l

upstream raw materials:

(1,1-dimethylethyl) 4-[[2-butyl-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]benzoate

Downstream raw materials:

(1,1-dimethyl) 4-[[2-butyl-5-[[2-(phenylmethoxycarbonyl)phenyl]aminomethyl]-1H-imidazol-1-yl]methyl]benzoate

4-[[2-butyl-5-[[2-(phenylmethoxycarbonyl)phenyl]aminomethyl]-1H-imidazol-1-yl]methyl]benzoic acid

benzyl 2-[[[2-butyl-1-[(4-((((2-chloro-4-iodophenyl)sulfonyl)amino)carbonyl)phenyl)methyl]-1H-imidaazol-5-yl]methyl]amino]benzoate

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