(1,1-dimethylethyl) 4-[[2-butyl-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]benzoate

Base Information

• Chemical Name: (1,1-dimethylethyl) 4-[[2-butyl-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]benzoate
• CAS No.: 155764-19-5
• Molecular Formula: C₂₀H₂₈N₂O₃
• Molecular Weight: 344.454
• Mol file: 155764-19-5.mol

Synonyms:(1,1-dimethylethyl) 4-[[2-butyl-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]benzoate

Chemical Property of (1,1-dimethylethyl) 4-[[2-butyl-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1,1-dimethylethyl) 4-[[2-butyl-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]benzoate

There total 1 articles about (1,1-dimethylethyl) 4-[[2-butyl-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dimethylethyl 4-<(2-butyl-5-formyl-1H-imidazol-1-yl)methyl>benzoate → (1,1-dimethylethyl) 4-[[2-butyl-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]benzoate (155764-19-5)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.25h;

DOI:10.1021/jm991050l

Reference yield: 97.0%

(1,1-dimethylethyl) 4-[[2-butyl-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]benzoate (155764-19-5) → (1,1-dimethylethyl) 4-[[2-butyl-5-(chloromethyl)-1H-imidazol-1-yl]methyl]benzoate (155764-35-5)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 - 20 ℃; for 0.0833333h;

DOI:10.1021/jm991050l

Reference yield:

(1,1-dimethylethyl) 4-[[2-butyl-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]benzoate (155764-19-5) → benzyl 2-[[[2-butyl-1-[(4-((((2-chloro-4-t-phenyl)sulfonyl)amino)carbonyl)phenyl)methyl]-1H-imidaazol-5-yl]methyl]amino]benzoate

Guidance literature:

Multi-step reaction with 5 steps

1: 97 percent / SOCl₂ / CH₂Cl₂ / 0.08 h / 0 - 20 °C

2: 50 percent / 2,6-lutidine / toluene / 1 h / Heating

3: 94 percent / TFA / 3 h / 0 °C

4: 69 percent / DMAP; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 96 h / 20 °C

5: [⁽³⁾H]2; Et₃N / 10 percent Pd/C / dimethylformamide / 6 h / 20 °C / 760 Torr

With 2,6-dimethylpyridine; dmap; thionyl chloride; tritium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide; toluene; 1: Substitution / 2: Alkylation / 3: Hydrolysis / 4: Condensation / 5: Substitution;

DOI:10.1021/jm991050l

Downstream raw materials:

(1,1-dimethylethyl) 4-[[2-butyl-5-(chloromethyl)-1H-imidazol-1-yl]methyl]benzoate

4-[[2-butyl-5-[[2-(phenylmethoxycarbonyl)phenyl]aminomethyl]-1H-imidazol-1-yl]methyl]benzoic acid

(1,1-dimethyl) 4-[[2-butyl-5-[[2-(phenylmethoxycarbonyl)phenyl]aminomethyl]-1H-imidazol-1-yl]methyl]benzoate

benzyl 2-[[[2-butyl-1-[(4-((((2-chloro-4-iodophenyl)sulfonyl)amino)carbonyl)phenyl)methyl]-1H-imidaazol-5-yl]methyl]amino]benzoate