benzyl 2-[[[2-butyl-1-[(4-((((2-chloro-4-iodophenyl)sulfonyl)amino)carbonyl)phenyl)methyl]-1H-imidaazol-5-yl]methyl]amino]benzoate

Base Information

Chemical Name:benzyl 2-[[[2-butyl-1-[(4-((((2-chloro-4-iodophenyl)sulfonyl)amino)carbonyl)phenyl)methyl]-1H-imidaazol-5-yl]methyl]amino]benzoate
CAS No.:250363-66-7
Molecular Formula:C₃₆H₃₄ClIN₄O₅S
Molecular Weight:797.113
Hs Code.:

Synonyms:benzyl 2-[[[2-butyl-1-[(4-((((2-chloro-4-iodophenyl)sulfonyl)amino)carbonyl)phenyl)methyl]-1H-imidaazol-5-yl]methyl]amino]benzoate

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Chemical Property of benzyl 2-[[[2-butyl-1-[(4-((((2-chloro-4-iodophenyl)sulfonyl)amino)carbonyl)phenyl)methyl]-1H-imidaazol-5-yl]methyl]amino]benzoate

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Technology Process of benzyl 2-[[[2-butyl-1-[(4-((((2-chloro-4-iodophenyl)sulfonyl)amino)carbonyl)phenyl)methyl]-1H-imidaazol-5-yl]methyl]amino]benzoate

There total 6 articles about benzyl 2-[[[2-butyl-1-[(4-((((2-chloro-4-iodophenyl)sulfonyl)amino)carbonyl)phenyl)methyl]-1H-imidaazol-5-yl]methyl]amino]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 2-chloro-4-iodobenzenesulfonamide

: 155741-38-1
4-[[2-butyl-5-[[2-(phenylmethoxycarbonyl)phenyl]aminomethyl]-1H-imidazol-1-yl]methyl]benzoic acid

: 250363-66-7
benzyl 2-[[[2-butyl-1-[(4-((((2-chloro-4-iodophenyl)sulfonyl)amino)carbonyl)phenyl)methyl]-1H-imidaazol-5-yl]methyl]amino]benzoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 96h;
DOI:10.1021/jm991050l

Reference yield:

: 82185-41-9
benzyl anthranilate

: 250363-66-7
benzyl 2-[[[2-butyl-1-[(4-((((2-chloro-4-iodophenyl)sulfonyl)amino)carbonyl)phenyl)methyl]-1H-imidaazol-5-yl]methyl]amino]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / 2,6-lutidine / toluene / 1 h / Heating

2: 94 percent / TFA / 3 h / 0 °C

3: 69 percent / DMAP; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 96 h / 20 °C

With 2,6-dimethylpyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; toluene; 1: Alkylation / 2: Hydrolysis / 3: Condensation;
DOI:10.1021/jm991050l

Reference yield:

: 1,1-dimethylethyl 4-<(2-butyl-5-formyl-1H-imidazol-1-yl)methyl>benzoate

: 250363-66-7
benzyl 2-[[[2-butyl-1-[(4-((((2-chloro-4-iodophenyl)sulfonyl)amino)carbonyl)phenyl)methyl]-1H-imidaazol-5-yl]methyl]amino]benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH₄ / methanol / 0.25 h / 0 °C

2: 97 percent / SOCl₂ / CH₂Cl₂ / 0.08 h / 0 - 20 °C

3: 50 percent / 2,6-lutidine / toluene / 1 h / Heating

4: 94 percent / TFA / 3 h / 0 °C

5: 69 percent / DMAP; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 96 h / 20 °C

With 2,6-dimethylpyridine; dmap; sodium tetrahydroborate; thionyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In methanol; dichloromethane; toluene; 1: Reduction / 2: Substitution / 3: Alkylation / 4: Hydrolysis / 5: Condensation;
DOI:10.1021/jm991050l