4-(4-(3-chlorobenzyl)piperazine-1-carbonyl)-N-(4-oxo-4H-3,1-benzothiazin-2-yl)benzamide

Base Information

Chemical Name:4-(4-(3-chlorobenzyl)piperazine-1-carbonyl)-N-(4-oxo-4H-3,1-benzothiazin-2-yl)benzamide
CAS No.:1439488-70-6
Molecular Formula:C₂₇H₂₃ClN₄O₃S
Molecular Weight:519.024
Hs Code.:

Synonyms:4-(4-(3-chlorobenzyl)piperazine-1-carbonyl)-N-(4-oxo-4H-3,1-benzothiazin-2-yl)benzamide

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Chemical Property of 4-(4-(3-chlorobenzyl)piperazine-1-carbonyl)-N-(4-oxo-4H-3,1-benzothiazin-2-yl)benzamide

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Technology Process of 4-(4-(3-chlorobenzyl)piperazine-1-carbonyl)-N-(4-oxo-4H-3,1-benzothiazin-2-yl)benzamide

There total 6 articles about 4-(4-(3-chlorobenzyl)piperazine-1-carbonyl)-N-(4-oxo-4H-3,1-benzothiazin-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1370034-99-3
4-(4-oxo-4H-3,1-benzothiazin-2-ylcarbamoyl)benzoic acid

: 23145-91-7
1-(3-chlorobenzyl)piperazine

: 1439488-70-6
4-(4-(3-chlorobenzyl)piperazine-1-carbonyl)-N-(4-oxo-4H-3,1-benzothiazin-2-yl)benzamide

Guidance literature:: 4-(4-oxo-4H-3,1-benzothiazin-2-ylcarbamoyl)benzoic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

1-(3-chlorobenzyl)piperazine; With 1H-imidazole; hydrogenchloride; In 1,4-dioxane; N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/jm400336x

Reference yield:

N-benzoyl-N'-(2-carboxyphenyl)thiourea: 13277-24-2
N-benzoyl-N'-(2-carboxyphenyl)thiourea

: 1439488-70-6
4-(4-(3-chlorobenzyl)piperazine-1-carbonyl)-N-(4-oxo-4H-3,1-benzothiazin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 4 h / 100 °C

2.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 20 °C

2.2: 2 h / Reflux

3.1: potassium peroxymonosulfate / N,N-dimethyl-formamide / 12 h / 20 °C

4.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 20 °C

4.2: 2 h / 20 °C

With potassium peroxymonosulfate; oxalyl dichloride; sulfuric acid; N,N-dimethyl-formamide; 1,1'-carbonyldiimidazole; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm400336x

Reference yield:

: C₁₆H₁₀N₂O₃S

: 1439488-70-6
4-(4-(3-chlorobenzyl)piperazine-1-carbonyl)-N-(4-oxo-4H-3,1-benzothiazin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium peroxymonosulfate / N,N-dimethyl-formamide / 12 h / 20 °C

2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 2 h / 20 °C

With potassium peroxymonosulfate; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide;
DOI:10.1021/jm400336x