13277-24-2

Basic information

• Product Name: 2-{[(phenylcarbonyl)carbamothioyl]amino}benzoic acid
• CAS NO: 13277-24-2
• Molecular Formula: C₁₅H₁₂N₂O₃S
• Molecular Weight: 300.3324
• Mol File: 13277-24-2.mol
• Article Data: 5

Chemical Properties

• Density: 1.422g/cm³
• Refractive Index: 1.718
• CAS DataBase Reference: 2-{[(phenylcarbonyl)carbamothioyl]amino}benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{[(phenylcarbonyl)carbamothioyl]amino}benzoic acid(13277-24-2)
• EPA Substance Registry System: 2-{[(phenylcarbonyl)carbamothioyl]amino}benzoic acid(13277-24-2)

Safety Data

• Hazardous Substances Data: 13277-24-2(Hazardous Substances Data)

Usage

Structure

A derivative of benzoic acid with a phenylcarbonyl carbamothioyl amino group attached

Usage

Often used in pharmaceutical research and drug development as a potential bioactive molecule

Potential

May have applications in the development of new therapeutic agents

Research

Further research is needed to fully understand and harness its medicinal potential.

Upstream product

• 131357-77-2 N-(4-oxo-4H-benzo[d][1,3]thiazin-2-yl)benzamide 
• 1147550-11-5 ammonium thiocyanate 
• 98-88-4 benzoyl chloride 
• 118-92-3 anthranilic acid 
• 532-55-8 Benzoyl isothiocyanate 

Downstream Products

• 13906-09-7 2-thioxo-2,3-dihydro-1H-quinazolin-4-one 
• 113580-76-0 3-Benzoyl-4-oxo-2-thioxo-1,2,3,4-tetrahydrochinazolin 
• 1439488-65-9 4-(4-(2-chlorobenzyl)piperazine-1-carbonyl)-N-(4-oxo-4H-3,1-benzothiazin-2-yl)benzamide 
• 1439488-70-6 4-(4-(3-chlorobenzyl)piperazine-1-carbonyl)-N-(4-oxo-4H-3,1-benzothiazin-2-yl)benzamide 
• 1439488-75-1 4-(4-(4-chlorobenzyl)piperazine-1-carbonyl)-N-(4-oxo-4H-3,1-benzothiazin-2-yl)benzamide 
• 1439487-76-9 N-(4-oxo-4H-3,1-benzothiazin-2-yl)-3-phenylpropanamide 
• 1370035-00-9 4-(4-methylpiperazine-1-carbonyl)-N-(4-oxo-4H-3,1-benzothiazin-2-yl)benzamide 
• 1370034-98-2 4-aminomethyl-N-(4-oxo-4H-3,1-benzothiazin-2-yl)benzamide hydrochloride 
• 1370034-97-1 tert-butyl (4-oxo-4H-3,1-benzothiazin-2-ylcarbamoyl)-benzylcarbamate 
• 1370034-94-8 N-(4-oxo-4H-3,1-benzothiazin-2-yl)-2-phenylacetamide 
• 1370035-01-0 4-(4-benzylpiperazine-1-carbonyl)-N-(4-oxo-4H-3,1-benzothiazin-2-yl)benzamide 
• 1370034-99-3 4-(4-oxo-4H-3,1-benzothiazin-2-ylcarbamoyl)benzoic acid 
• 1370034-96-0 4-formyl-N-(4-oxo-4H-3,1-benzothiazin-2-yl)benzamide 
• 1370034-95-9 3-cyclohexyl-N-(4-oxo-4H-3,1-benzothiazin-2-yl)propionamide 

Relevant articles and documents

P(III)-Mediated Cascade C-N/C-S Bond Formation: A Protocol towards the Synthesis of N,S-Heterocycles and Spiro Compounds

A P(III)-mediated entry towards construction of C?N/C?S bond has been devised. The developed heterocyclization method was exercised for the synthesis of a diverse range of N,S-heterocycles and related spiro molecules. P(NMe2)3 revealed the maximum efficacies under the aerobic reaction conditions and a spectrum of bis-nucleophiles, and isothiocyanates were tolerated well to serve the access of manifold immense molecules. (Figure presented.).

Synthesis and biological activity of N-aroyl-N′-substituted thiourea derivatives

A series of N-aroyl-N′-substituted thiourea derivatives have been prepared in good to excellent yields under the condition of solid-liquid phase transfer catalysis using polyethylene glycol-400(PEG-400) as the catalyst. The products have been characterize

REACTIONS OF N-BENZOYL ISOTHIOCYANATE WITH ANTHRANILIC ACID AND METHYL ANTHRANILATE

N-Benzoyl-N'-(2-carboxy- and -2-methoxycarbonylphenyl)thioureas have been obtained by the reaction of N-benzoyl isothiocyanate with anthranilic acid and methyl anthranilate, respectively.Kinetics of cyclization of these compounds into 2-mercapto-3,4-dihydro-4-quinazolone have been studied in water and in methanol.In the base-catalyzed cyclization of N-benzoyl-N'-(2-carboxyphenyl)thiourea the proper cyclization is preceded by solvolysis of the benzoyl group.In the case of N-benzoyl-N'-(2-methoxycarbonylphenyl)thiourea the reaction rate is limited by the base-catalyzed cyclization of the starting benzoyl derivative; the benzoyl group is split off in a subsequent rapid step.